Dynamics of the Streptomyces chromosome: chance and necessity.
In: Trends in Genetics, Jg. 39 (2023-11-01), Heft 11, S. 873-887
academicJournal
Zugriff:
Streptomyces possess a linear, genetically compartmentalized chromosome. Core genes (conserved across the genus) are grouped in the central part, while terminal regions are populated by poorly conserved genes including clusters encoding antibiotic production. The genome is highly plastic: the Streptomyces pangenome is at least 2 logs larger than the core genome (i.e., all core genes). The Streptomyces chromosome is unstable, exhibiting a stable backbone in the central region and an evolutionary gradient towards fast-evolving arms. The genetic compartmentalization correlates with chromosome 3D folding in the exponential phase. The distal rRNA (rrn) operons delimit a highly structured and expressed region termed the 'central compartment', exhibiting structural features distinct from those of the 'terminal compartments', which are almost transcriptionally quiescent. The chromosome spatial conformation changes over the developmental cycle from a rather open to a closed conformation. Streptomyces are prolific producers of specialized metabolites with applications in medicine and agriculture. Remarkably, these bacteria possess a large linear chromosome that is genetically compartmentalized: core genes are grouped in the central part, while the ends are populated by poorly conserved genes including antibiotic biosynthetic gene clusters. The genome is highly unstable and exhibits distinct evolutionary rates along the chromosome. Recent chromosome conformation capture (3C) and comparative genomics studies have shed new light on the interplay between genome dynamics in space and time. Here, we review insights that illustrate how the balance between chance (random genome variations) and necessity (structural and functional constraints) may have led to the emergence of spatial structuring of the Streptomyces chromosome. [ABSTRACT FROM AUTHOR]
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Dynamics of the Streptomyces chromosome: chance and necessity.
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Autor/in / Beteiligte Person: | Bury-Moné, Stéphanie ; Thibessard, Annabelle ; Lioy, Virginia S. ; Leblond, Pierre |
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Zeitschrift: | Trends in Genetics, Jg. 39 (2023-11-01), Heft 11, S. 873-887 |
Veröffentlichung: | 2023 |
Medientyp: | academicJournal |
ISSN: | 0168-9525 (print) |
DOI: | 10.1016/j.tig.2023.07.008 |
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