Coronavirus-19 disease risk and protective factors associated with HLA/KIR polymorphisms in Ecuadorian patients residing in Madrid.
In: Human Immunology, Jg. 84 (2023-11-01), Heft 11, S. 571-577
academicJournal
Zugriff:
Immigrants represented 21.8% of cases in a Spanish cohort of hospitalised patients with COVID-19, a proportion exceeding the percentage of immigrants in that area's total population. Among the ethnic-related genetic risk factors for COVID-19, human leukocyte antigen (HLA) genotypes in diverse populations might bias the response to SARS-CoV-2 infection and/or progression. Similarly, genetic differences in natural killer-activating and inhibitory receptors could play a role in the immune system's response to the viral infection. We characterised HLA alleles and KIR genes in 52 Ecuadorian patients hospitalised for moderate and severe COVID-19 and 87 Ecuadorian controls from the general population living in the same area. There was a significantly increased frequency of the HLA-B*39 antigen and the activating KIR2DS4 receptor in the presence of its HLA-C*04 ligand in the COVID-19 group when compared with the control group. In contrast, there was a significant reduction in the frequency of carriers of KIR2DL1 and of the KIR3DL1/Bw4 receptor/ligand combination among COVID-19 group. On the other hand, HLA-A*24:02 and HLA-DRB1*09:01 alleles showed significantly lower frequencies specifically in the severe COVID-19 group. HLA-B*39 alleles might be genetic risk factors for developing COVID-19 in Ecuadorian individuals. In the presence of its ligand C*04, the natural killer-activating receptor KIR2DS4 might also increase the risk of developing COVID-19, while, in the presence of HLA-Bw4 alleles, the inhibitory receptor KIR3DL1 might play a protective role. Patients with COVID-19 who carry HLA-A*24:02 and HLA-DRB1*09:01 alleles might be protected against more severe forms of COVID-19. [ABSTRACT FROM AUTHOR]
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Coronavirus-19 disease risk and protective factors associated with HLA/KIR polymorphisms in Ecuadorian patients residing in Madrid.
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Autor/in / Beteiligte Person: | Balas, Antonio ; Moreno-Hidalgo, Miguel Ángel ; de la Calle-Prieto, Fernando ; Vicario, José Luis ; Arsuaga, Marta ; Trigo, Elena ; de Miguel-Buckley, Rosa ; Bellón, Teresa ; Díaz-Menéndez, Marta |
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Zeitschrift: | Human Immunology, Jg. 84 (2023-11-01), Heft 11, S. 571-577 |
Veröffentlichung: | 2023 |
Medientyp: | academicJournal |
ISSN: | 0198-8859 (print) |
DOI: | 10.1016/j.humimm.2023.09.004 |
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