Baseline Cohort Profile of the Korean Chronic Cough Registry: A Multicenter, Prospective, Observational Study.
In: Lung, Jg. 201 (2023-10-01), Heft 5, S. 477-488
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academicJournal
Zugriff:
Purpose: The Korean Chronic Cough Registry study was initiated to characterize patients with chronic cough (CC) and investigate their outcomes in real-world clinical practice. This report aims to describe the baseline cohort profile and study protocols. Methods: This multicenter, prospective observational cohort study included newly referred CC patients and those already being treated for refractory or unexplained chronic cough (RUCC). Cough status was assessed using a visual analog scale, the Leicester Cough Questionnaire (LCQ), and the Cough Hypersensitivity Questionnaire (CHQ). Results: A total of 610 patients (66.9% women; median age 59.0 years) were recruited from 18 centers, with 176 being RUCC patients (28.9%). The median age at CC onset was 50.1 years, and 94.4% had adult-onset CC (≥ 19 years). The median cough duration was 4 years. Compared to newly referred CC patients, RUCC patients had a longer cough duration (6.0 years vs. 3.0 years) but had fewer symptoms and signs suggesting asthma, rhinosinusitis, or gastroesophageal acid reflux disease. Subjects with RUCC had lower LCQ scores (10.3 ± 3.3 vs. 11.6 ± 3.6; P < 0.001) and higher CHQ scores (9.1 ± 3.9 vs. 8.4 ± 4.1; P = 0.024). There were no marked differences in the characteristics of cough between refractory chronic cough and unexplained chronic cough. Conclusions: Chronic cough typically develops in adulthood, lasting for years. Cough severity and quality of life impairment indicate the presence of unmet clinical needs and insufficient cough control in real-world clinical practice. Longitudinal follow-up is warranted to investigate the natural history and treatment outcomes. [ABSTRACT FROM AUTHOR]
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Baseline Cohort Profile of the Korean Chronic Cough Registry: A Multicenter, Prospective, Observational Study.
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Autor/in / Beteiligte Person: | Jo, Eun-Jung ; Lee, Ji-Hyang ; Won, Ha-Kyeong ; Kang, Noeul ; Kang, Sung-Yoon ; Lee, Seung Eun ; Lee, Ji-Ho ; Kim, Mi-Yeong ; Shim, Ji-Su ; An, Jin ; Yoo, Youngsang ; Park, So-Young ; Kim, Byung-Keun ; Moon, Ji-Yong ; Park, Han-Ki ; Kim, Min-Hye ; Kwon, Hyouk-Soo ; Kim, Sae-Hoon ; Kim, Sang-Heon ; Chang, Yoon-Seok |
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Zeitschrift: | Lung, Jg. 201 (2023-10-01), Heft 5, S. 477-488 |
Veröffentlichung: | 2023 |
Medientyp: | academicJournal |
ISSN: | 0341-2040 (print) |
DOI: | 10.1007/s00408-023-00644-4 |
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