Tracking the super resolved structure of mitochondria using red emissive carbon nanodots as a fluorescent biomarker.
In: Chemical Communications, Jg. 59 (2023-11-21), Heft 90, S. 13454-13457
academicJournal
Zugriff:
Herein, we report new red emissive highly photostable and water-soluble carbon nanodots (TPP CNDs) to visualize mitochondrial dynamics using super-resolution radial fluctuations (SRRF) microscopy. The TPP CNDs were synthesized in a one-step method, using 3-(carboxypropyl)triphenylphosphonium bromide (TPP) and o-phenylenediamine (OPDA) as precursors. The obtained crystal structure, NMR, and mass data suggested the presence of [3-(1H-benzimidazol-2-yl)propyl](triphenyl)phosphonium bromide (C28H26N2P+Br−) as a molecular fluorophore (MF) on the surface of the TPP CNDs. The TPP CNDs showed better photostability than the commercially available MitoTracker™ Green and were highly capable for long-term imaging of mitochondrial fission during hyperglycemic conditions and structural changes upon an antidiabetic drug treatment, without altering their fluorescence nature. [ABSTRACT FROM AUTHOR]
| Titel: |
Tracking the super resolved structure of mitochondria using red emissive carbon nanodots as a fluorescent biomarker.
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| Autor/in / Beteiligte Person: | Garg, Richa ; Anjum, Farhan ; Salam, Abdul ; Kaushik, Kush ; Sharma, Shagun ; Sahrawat, Udisha ; Yadav, Aditya ; Nandi, Chayan Kanti |
| Zeitschrift: | Chemical Communications, Jg. 59 (2023-11-21), Heft 90, S. 13454-13457 |
| Veröffentlichung: | 2023 |
| Medientyp: | academicJournal |
| ISSN: | 1359-7345 (print) |
| DOI: | 10.1039/d3cc03390b |
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