Small Jab1-containing subcomplex is regulated in an anchorage- and cell cycle-dependent manner, which is abrogated by ras transformation
In: FEBS Letters, Jg. 579 (2005-02-14), Heft 5, S. 1047-1054
Online
academicJournal
Zugriff:
Abstract: Jab1 interacts with a variety of cell cycle and signal transduction regulators to control cell proliferation, differentiation, and tumorigenesis. In this study, we employed a non-denaturing gel electrophoresis method to separate different Jab1-containing complexes, the COP9 signalosome complex and the small Jab1-containing subcomplex. The formation of the small Jab1 complex was dependent on a low cell density and anchorage to a solid support, and enhanced during the early G1 phase of the cell cycle, which was abrogated in ras-transformed cells. The small Jab1-containing subcomplex may be a novel mediator of anchorage and cell–cell contact-dependent signal transduction. [Copyright &y& Elsevier]
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Small Jab1-containing subcomplex is regulated in an anchorage- and cell cycle-dependent manner, which is abrogated by ras transformation
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Autor/in / Beteiligte Person: | Fukumoto, Akihisa ; Tomoda, Kiichiro ; Kubota, Makoto ; Kato, Jun-ya ; Yoneda-Kato, Noriko |
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Zeitschrift: | FEBS Letters, Jg. 579 (2005-02-14), Heft 5, S. 1047-1054 |
Veröffentlichung: | 2005 |
Medientyp: | academicJournal |
ISSN: | 0014-5793 (print) |
DOI: | 10.1016/j.febslet.2004.12.076 |
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