Not all 2',4'-bridged modifications stabilize DNA/RNA duplexes.
In: Nucleosides, Nucleotides & Nucleic Acids, Jg. 43 (2024), Heft 1, S. 57-64
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Zugriff:
2',4'-Bridged modifications such as 2'-O,4'-C-methylene-bridged nucleotides (LNAs) and 2'-O,4'-C-ethylene-bridged nucleotides (ENAs) provide high binding affinity for duplex formation. Stabilization by the introduction of the bridged nucleic acids is considered to be due to pre-organization. In this study, we found that the introduction of 2',4'-C-bridged 2'-deoxynucleotides (CRNs; Conformationally Restricted Nucleotides) into DNA/RNA duplexes leads to destabilization, as opposed to the previously accepted notion that 2',4'-bridged modifications always lead to stabilization. [ABSTRACT FROM AUTHOR]
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Not all 2',4'-bridged modifications stabilize DNA/RNA duplexes.
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| Autor/in / Beteiligte Person: | Akita, Tomoka ; Tomita-Sudo, Elisa ; Itoh, Shin ; Sakimoto, Nae ; Masuda, Takeshi ; Nakamura, Akifumi ; Onishi, Yoshiyuki ; Koizumi, Makoto ; Kawakami, Junji |
| Zeitschrift: | Nucleosides, Nucleotides & Nucleic Acids, Jg. 43 (2024), Heft 1, S. 57-64 |
| Veröffentlichung: | 2024 |
| Medientyp: | academicJournal |
| ISSN: | 1525-7770 (print) |
| DOI: | 10.1080/15257770.2023.2232414 |
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