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Efficacy and Safety of Lidocam Topical Gel (4% Lidocaine—0.3% Meloxicam) for Pain and Inflammation Management during Castration and Tail Docking in Piglets.
In: Animals (2076-2615), Jg. 14 (2024-03-15), Heft 6, S. 930-952
Online
academicJournal
Zugriff:
Simple Summary: In most high-income countries, piglets undergo certain elective surgical procedures such as castration and tail docking to eliminate behaviors that are associated with mortality and the condemnation of animals and meat. It has been well established that both castration and tail docking are both painful, yet there are limited products for addressing short-term and long-term pain. Lidocam™ Topical Gel (LTG) (4% lidocaine and 0.3% meloxicam) was developed to address the animal welfare and production requirements of the swine industry. The studies described in this paper show that applications of LTG to the scrotal area and tail base act to control the pain associated with these surgical procedure. The studies also demonstrate that LTG was able to control pain and inflammation at the surgical sites for at least 24 h after application. This was demonstrated by using established physiological and behavioral markers for surgical pain: plasma cortisol and substance P, vocalization during procedure, electrocutaneous stimulation of surgical site, and body weight gain. LTG is potentially an effective product for controlling pain and inflammation for use in castration and tail docking in piglets. (1) Background: It has been well established that castration and tail docking are both painful during and following the procedure, yet there are limited convenient and effective products to address both short-term and long-term pain. Lidocam Topical Gel (LTG) (4% lidocaine and 0.3% meloxicam) was developed to address industry needs for an effective and safe product to address animal welfare concerns regarding castration and tail docking in piglets. (2) Methods: Study 1: Male piglets aged 4–8 days of age were treated with LTG (n = 30) or a control gel (n = 30). Approximately 30 min after application of the gel, the piglets were surgically castrated and tail docked. The efficacy of pain control during the surgical procedures and post-procedure (24 h) pain and inflammation control were evaluated using both behavioral and physiological measurements. Study 2: Meloxicam residue depletion following LTG treatment was followed for 28 days. Study 3: Clinical and pathological safety were evaluated in five groups of eight piglets receiving LTG with: (1) no treatment, (2) nominal topical dose, (3) two times the nominal topical dose, (4) three times the nominal topical dose, and 5) one times the nominal topical dose and 2 mL of LTG by oral gavage daily for 3 days. (3) Results: LTG-treated piglets had a significant reduction in electrocutaneous stimulation response before the procedures and 4 and 24 h post-procedures. Stress vocalization intensity and duration were less in piglets receiving LTG during the surgical procedures. Plasma cortisol and substance P were significantly lower in LTG-treated piglets 3 h after castration and tail docking. The weight and average daily gain were significantly increased in piglets receiving LTG. LTG did not interfere with wound healing or cause irritation at the application sites. There were no abnormal clinical or pathological findings associated with the use of LTG at three times the nominal dose given daily for three days. As meloxicam persisted in the application site tissue, a slaughter withdrawal time of 24 days was determined. (4) Conclusions: When applied to the skin 30 min before castration and tail docking, LTG is effective in surgical pain control and provides post-surgical pain control for up to 24 h. LTG is safe for use in piglets and provides an acceptable withdrawal time for commercial use. LTG is a potentially effective product for commercial use for piglet castration and tail docking. [ABSTRACT FROM AUTHOR]
Titel: |
Efficacy and Safety of Lidocam Topical Gel (4% Lidocaine—0.3% Meloxicam) for Pain and Inflammation Management during Castration and Tail Docking in Piglets.
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Autor/in / Beteiligte Person: | Nagel, Denis ; Ralston, Brenda ; Hanson, Andrea ; Burwash, Les ; Matheson-Bird, Heather ; Olson, Barbara ; Schatz, Crystal ; Olson, Merle |
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Zeitschrift: | Animals (2076-2615), Jg. 14 (2024-03-15), Heft 6, S. 930-952 |
Veröffentlichung: | 2024 |
Medientyp: | academicJournal |
ISSN: | 2076-2615 (print) |
DOI: | 10.3390/ani14060930 |
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