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Successful therapy with tenofovir disoproxil fumarate (TDF) in patients with chronic hepatitis B (CHB) does not guarantee amelioration of liver damage assessing by transient elastography. A retrospective - prospective multicenter study.
In: BMC Gastroenterology, Jg. 24 (2024-04-12), Heft 1, S. 1-8
Online
academicJournal
Zugriff:
Background: Preventing disease progression and viral suppression are the main goals of antiviral therapy in chronic hepatitis B (CHB). Liver stiffness measurement (LSM) by transient elastography is a reliable non-invasive method to assess liver fibrosis in patients with CHB. Our aim was to explore factors that may affect changes in LSMs during long term tenofovir (TDF) monotherapy in a well characterized cohort of patients with compensated CHB. Methods: We analyzed serial LSMs in 103 adult patients with CHB who were on TDF monotherapy and had at least three LSMs over a period of 90 months. Results: Twenty-five (24%) patients had advanced fibrosis at baseline. A significant decline in mean LSM between baseline and last visit (8.7 ± 6.2 kPa vs. 6.7 ± 3.3, p = 10− 3) was observed. Twenty-four (23%) patients had progression of liver fibrosis with mean increase in liver stiffness of 2.8 kPa (range: 0.2–10.2 kPa). Multivariate analysis showed that BMI ≥ 25 (OR, 0.014; 95% CI, 0.001–0.157; p = 0.001) and advanced fibrosis (OR, 5.169; 95% CI, 1.240–21.540; p = 0.024) were independently associated with a fibrosis regression of > 30% of liver stiffness compared to baseline value. Conclusions: In CHB patients TDF monotherapy resulted in liver fibrosis regression, especially in patients with advanced fibrosis. Despite the successful antiviral effect of TDF, 1 out of 4 patients had liver fibrosis progression. Obesity and advanced fibrosis at baseline were independently associated with significant liver fibrosis regression. [ABSTRACT FROM AUTHOR]
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Successful therapy with tenofovir disoproxil fumarate (TDF) in patients with chronic hepatitis B (CHB) does not guarantee amelioration of liver damage assessing by transient elastography. A retrospective - prospective multicenter study.
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Autor/in / Beteiligte Person: | Kranidioti, Hariklia ; Zisimopoulos, Konstantinos ; Oikonomou, Theodora ; Voulgaris, Theodoros ; Siakavellas, Spyros ; Agorastou, Polixeni ; Deutsch, Melanie ; Triantos, Christos ; Goulis, Ioannis ; Papatheodoridis, George ; Manolakopoulos, Spilios |
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Zeitschrift: | BMC Gastroenterology, Jg. 24 (2024-04-12), Heft 1, S. 1-8 |
Veröffentlichung: | 2024 |
Medientyp: | academicJournal |
ISSN: | 1471-230X (print) |
DOI: | 10.1186/s12876-024-03200-3 |
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