Solar ultraviolet radiation exposure, and incidence of childhood acute lymphocytic leukaemia and non-Hodgkin lymphoma in a US population-based dataset.
In: British Journal of Cancer, Jg. 130 (2024-05-18), Heft 9, S. 1441-1452
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Zugriff:
Background: Acute lymphocytic leukaemia (ALL) and non-Hodgkin lymphoma (NHL) are among the commonest types of childhood cancer. Some previous studies suggested that elevated ultraviolet radiation (UVR) exposures increase ALL risk; many more indicate NHL risk is reduced. Methods: We assessed age<20 ALL/NHL incidence in Surveillance, Epidemiology and End Results data using AVGLO-derived UVR irradiance/cumulative radiant exposure measures, using quasi-likelihood models accounting for underdispersion, adjusted for age, sex, racial/ethnic group and other county-level socioeconomic variables. Results: There were 30,349 cases of ALL and 8062 of NHL, with significant increasing trends of ALL with UVR irradiance (relative risk (RR) = 1.200/mW/cm2 (95% CI 1.060, 1.359, p = 0.0040)), but significant decreasing trends for NHL (RR = 0.646/mW/cm2 (95% CI 0.512, 0.816, p = 0.0002)). There was a borderline-significant increasing trend of ALL with UVR cumulative radiant exposure (RR = 1.444/MJ/cm2 (95% CI 0.949, 2.197, p = 0.0865)), and significant decreasing trends for NHL (RR = 0.284/MJ/cm2 (95% CI 0.166, 0.485, p < 0.0001)). ALL and NHL trend RR is substantially increased among those aged 0–3. All-age trend RRs are most extreme (increasing for ALL, decreasing for NHL) for Hispanics for both UVR measures. Conclusions: Our more novel finding, of excess UVR-related ALL risk, is consistent with some previous studies, but is not clear-cut, and in need of replication. [ABSTRACT FROM AUTHOR]
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Solar ultraviolet radiation exposure, and incidence of childhood acute lymphocytic leukaemia and non-Hodgkin lymphoma in a US population-based dataset.
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Autor/in / Beteiligte Person: | Little, Mark P. ; Mai, Jim Z. ; Fang, Michelle ; Chernyavskiy, Pavel ; Kennerley, Victoria ; Cahoon, Elizabeth K. ; Cockburn, Myles G. ; Kendall, Gerald M. ; Kimlin, Michael G. |
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Zeitschrift: | British Journal of Cancer, Jg. 130 (2024-05-18), Heft 9, S. 1441-1452 |
Veröffentlichung: | 2024 |
Medientyp: | academicJournal |
ISSN: | 0007-0920 (print) |
DOI: | 10.1038/s41416-024-02629-3 |
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