Efficacy, acceptability and tolerability of the combined contraceptive ring, NuvaRing, compared with an oral contraceptive containing 30 μg of ethinyl estradiol and 3 mg of drospirenone
In: Contraception, Jg. 74 (2006-12-01), Heft 6, S. 451-457
academicJournal
Zugriff:
Abstract: Purpose: This randomized multicenter, open-label, trial compared efficacy, acceptability, tolerability and compliance of NuvaRing with a combined oral contraceptive (COC), containing 30 μg of ethinyl estradiol (EE) and 3 mg of drospirenone. Method: In this 13-cycle study, 983 women were randomized and treated (intent-to-treat population) with NuvaRing or COC. Results: One in-treatment pregnancy occurred with NuvaRing (Pearl Index=0.25) (95% confidence interval [CI]: 0.006, 1.363) and four with the COC (Pearl Index=0.99) (95% CI: 0.269, 2.530). For both groups, compliance (89.2% NuvaRing, 85.5% COC) and satisfaction (84% NuvaRing; 87% COC) were high; the vast majority of women found NuvaRing easy to insert (96%) and remove (97%). Tolerability was similar; the most frequent adverse events with NuvaRing were related to ring use, whereas estrogen-related events were more common with the COC. Conclusion: NuvaRing has comparable efficacy and tolerability to a COC containing 30 μg of EE and 3 mg drospirenone. User acceptability of both methods was high. [Copyright &y& Elsevier]
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Efficacy, acceptability and tolerability of the combined contraceptive ring, NuvaRing, compared with an oral contraceptive containing 30 μg of ethinyl estradiol and 3 mg of drospirenone
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Autor/in / Beteiligte Person: | Ahrendt, Hans-Joachim ; Nisand, Israel ; Bastianelli, Carlo ; Gómez, Maria Angeles ; Gemzell-Danielsson, Kristina ; Urdl, Wolfgang ; Karskov, Birgit ; Oeyen, Luc ; Bitzer, Johannes ; Page, Geert ; Milsom, Ian |
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Zeitschrift: | Contraception, Jg. 74 (2006-12-01), Heft 6, S. 451-457 |
Veröffentlichung: | 2006 |
Medientyp: | academicJournal |
ISSN: | 0010-7824 (print) |
DOI: | 10.1016/j.contraception.2006.07.004 |
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