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Comparison of the effects of different drying techniques on properties of granules and tablets made on a production scale
In: International Journal of Pharmaceutics, Jg. 330 (2007-02-07), Heft 1/2, S. 99-104
academicJournal
Zugriff:
Abstract: The aims of this study were to compare the properties of granules prepared in a high-shear granulator and dried by using different methods (fluid-bed and microwave-vacuum drying) and to compare the properties of tablets pressed from such granules. Experiments on a production scale were performed with Collette Ultima Pro 600 single-pot processing equipment and a Glatt WSG 200 fluid-bed granulator and drier. The particles granulated in the traditional high-shear granulator and dried in a vacuum chamber had a higher porosity and higher bulk and tapped densities, as a consequence of the special characteristics of the drying process. They retained their spherical form, in contrast with the particles dried via the fluid-bed technology. The two types of granules required different compressing forces for tabletting. [Copyright &y& Elsevier]
Titel: |
Comparison of the effects of different drying techniques on properties of granules and tablets made on a production scale
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Autor/in / Beteiligte Person: | Hegedűs, Ágota ; Pintye-Hódi, Klára |
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Zeitschrift: | International Journal of Pharmaceutics, Jg. 330 (2007-02-07), Heft 1/2, S. 99-104 |
Veröffentlichung: | 2007 |
Medientyp: | academicJournal |
ISSN: | 0378-5173 (print) |
DOI: | 10.1016/j.ijpharm.2006.09.001 |
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