The Severity of Herpes Simplex Encephalitis is Modulated by Dietary Vitamin E.
In: FASEB Journal, Jg. 21 (2007-04-15), Heft 5, S. A376
Online
academicJournal
Zugriff:
Herpes simplex virus encephalitis (HSE) is the most common fatal sporadic encephalitis in humans. HSE is primarily caused by herpes simplex virus (HSV)-I infection of the brain. HSE results in increased levels of oxidative stress including the production of reactive oxygen species, free radicals and significant neuroinflammation. alpha-tocopherol is the most biologically active form of vitamin E (VE). In cellular membranes alpha-tocopherol prevents lipid peroxidation by scavenging free radicals and functions as an antioxidant. Supplementation with VE has been shown to decrease immunosenescence, improve immune function and may be neuroprotective. In order to determine how VE deficiency (VE def) and VE supplementation (VE 10x) would alter the pathogenesis of HSE, we placed weanling male BALB/cByJ mice on VE def, adq or 10x diets for 4 weeks and then infected them intranasally with HSV-1. VE def mice had more significant symptoms of encephalitis than VE adequate mice including weight loss, keratitis, hunched posture and morbidity. Interestingly, a 10x VE supplementation did not improve HSE symptoms compared with VE adq mice. Our results demonstrate that adequate levels of VE are important in limiting HSE pathology. [ABSTRACT FROM AUTHOR]
Titel: |
The Severity of Herpes Simplex Encephalitis is Modulated by Dietary Vitamin E.
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Autor/in / Beteiligte Person: | Sheridan, Patricia A. ; Beck, Melinda A. |
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Zeitschrift: | FASEB Journal, Jg. 21 (2007-04-15), Heft 5, S. A376 |
Veröffentlichung: | 2007 |
Medientyp: | academicJournal |
ISSN: | 0892-6638 (print) |
DOI: | 10.1096/fasebj.21.5.a376-d |
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