Protein-Resistant Silicones: Incorporation of Poly(ethylene oxide) via Siloxane Tethers.
In: Biomacromolecules, Jg. 8 (2007-10-08), Heft 10, S. 3244-3252
academicJournal
Zugriff:
Silicones with enhanced protein resistance were prepared by introducing poly(ethylene oxide) (PEO) chains via siloxane tethers (a−c)of varying lengths. Three unique ambifunctional molecules (a−c)having the general formula -(EtO)3Si(CH2)2-oligodimethylsiloxanen-block-poly(ethylene oxide)8-OCH3(n0 (a), 4, (b), and 13 (c)) were prepared via regioselective Rh-catalyzed hydrosilylation. Nine films were subsequently produced by the H3PO4-catalyzed sol−gel cross-linking of a−ceach with ,-bis(Si−OH)polydimethylsiloxane (P, Mn3000 g/mol) in varying ratios (1:1, 1:2, and 2:3 molar ratio a, b, or cto P). Films prepared with a 2:3 molar ratio (a−cto P) contained the least amount of un-cross-linked materials, which may migrate to the film surface. For this set of films, surface hydrophilicity and protein resistance increased with siloxane tether length (a−c). These results indicate that PEO was more effectively mobilized to the surface if incorporated into silicones via longer siloxane tethers. [ABSTRACT FROM AUTHOR]
Titel: |
Protein-Resistant Silicones: Incorporation of Poly(ethylene oxide) via Siloxane Tethers.
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Autor/in / Beteiligte Person: | Murthy, Ranjini ; Cox, Casey D. ; Hahn, Mariah S. ; Grunlan, Melissa A. |
Zeitschrift: | Biomacromolecules, Jg. 8 (2007-10-08), Heft 10, S. 3244-3252 |
Veröffentlichung: | 2007 |
Medientyp: | academicJournal |
ISSN: | 1525-7797 (print) |
DOI: | 10.1021/bm700543c |
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