Measurement and correlation of solute solubility in HFA-134a/ethanol systems
In: International Journal of Pharmaceutics, Jg. 362 (2008-10-01), Heft 1/2, S. 184-188
academicJournal
Zugriff:
Abstract: The goals of this study were to determine the solubility values of solid organic solutes in pure HFA-134a and in HFA-134a/ethanol cosolvent systems (0–20%, w/w), and to investigate the relationship between these solubilities and a solute''s physico-chemical properties. A direct inject on-line HPLC method was used to determine the solubility of 21 solutes in HFA-134a/ethanol. The samples were allowed to equilibrate for at least 48h. The filtered sample was injected directly on an analytical HPLC column through a manual injector interface, and analyzed at an appropriate solute wavelength via HPLC. The solutes display diverse physico-chemical properties and yielded solubility values that ranged over four orders of magnitude. In general, a linear–linear solubility relationship was observed as the fraction of ethanol increased. The effects on solubilization ranged from 1.3 to 99.4 times when 20% (w/w) ethanol was introduced, relative to pure HFA-134a. A regression equation utilizing a solute''s hydrogen bonding potential resulted in a significant correlation to the slope obtained from a linear model for solubility in HFA-134a with 0–20% (w/w) ethanol, and may be useful for pre-formulation studies. [Copyright &y& Elsevier]
Titel: |
Measurement and correlation of solute solubility in HFA-134a/ethanol systems
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Autor/in / Beteiligte Person: | Hoye, Julie A. ; Myrdal, Paul B. |
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Zeitschrift: | International Journal of Pharmaceutics, Jg. 362 (2008-10-01), Heft 1/2, S. 184-188 |
Veröffentlichung: | 2008 |
Medientyp: | academicJournal |
ISSN: | 0378-5173 (print) |
DOI: | 10.1016/j.ijpharm.2008.06.020 |
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