Effect of Tectona grandis Linn. on dexamethasone-induced insulin resistance in mice
In: Journal of Ethnopharmacology, Jg. 122 (2009-03-18), Heft 2, S. 304-307
academicJournal
Zugriff:
Abstract: Ethnopharmacological relevance: The bark of Tectona grandis Linn. is traditionally used in the treatment of diabetes. Aim: The present study was undertaken to investigate the effect of ethanolic extract of bark of Tectona grandis Linn. (TG) in dexamethasone-induced insulin resistance in mice. Materials and methods: Mice were treated with prestandardised dose of dexamethasone for 22 days and effect of TG at the doses of 50, 100 and 200mg/kg, p.o. on plasma blood glucose level, serum triglyceride level, glucose uptake in skeletal muscle, levels of hepatic antioxidant enzymes (GSH, SOD, catalase and LPO), and body weight were observed. Results: TG showed significant decrease in plasma glucose and serum triglyceride levels (p <0.01) at the dose of 100 and 200mg/kg, p.o. and also stimulated glucose uptake in skeletal muscle. The levels of antioxidant enzymes GSH, SOD, and catalase were significantly increased (p <0.01) and there was significant decrease (p <0.01) in level of LPO. Conclusion: Hence it can be concluded that Tectona grandis may prove to be effective in the treatment of Type-II Diabetes mellitus owing to its ability to decrease insulin resistance. [Copyright &y& Elsevier]
Titel: |
Effect of Tectona grandis Linn. on dexamethasone-induced insulin resistance in mice
|
---|---|
Autor/in / Beteiligte Person: | Ghaisas, Mahesh ; Navghare, Vijay ; Takawale, Abhijit ; Zope, Vinit ; Tanwar, Mukesh ; Deshpande, Avinash |
Link: | |
Zeitschrift: | Journal of Ethnopharmacology, Jg. 122 (2009-03-18), Heft 2, S. 304-307 |
Veröffentlichung: | 2009 |
Medientyp: | academicJournal |
ISSN: | 0378-8741 (print) |
DOI: | 10.1016/j.jep.2009.01.008 |
Schlagwort: |
|
Sonstiges: |
|