Diagnostic value of zinc protoporphyrin in a screening strategy for α-thalassemia.
In: European Journal of Haematology, Jg. 82 (2009-05-01), Heft 5, S. 393-397
Online
academicJournal
Zugriff:
The definitive diagnosis of α-thalassemia involves detection of a deletion of one or more α-globin that encode the α-chains of Hb (hemoglobin). To determine whether DNA analysis is indicated, screening tests such as mean corpuscular volume (MCV) and Hb typing are employed. α-Thalassemia often correlates with normal or low HbA2 values. Zinc protoporphyrin (ZPP) is usually high in ferropenic anemia or lead-poisoning and is normal or slightly raised in ß-thalassemia. Therefore, ZPP is currently used as a marker to discriminate between ferropenic anemia and β-thalassemia. We investigated the diagnostic potential of ZPP < 150 μmol/mol heme in a screening strategy for α-thalassemia. We measured ZPP and performed DNA analysis for detecting the seven most prevalent α-thalassemia deletions, namely, α3.7, SEA, α20.5, α4.2, MED, FIL, and THAI, in the blood samples of 200 patients with MCV < 70 fL and HbA2 ≤ 3.5%. Deletions were detected in 9% subjects in the ZPP ≥ 150 group ( n = 175) and 56% subjects in the ZPP < 150 group ( n = 29); this difference was statistically significant (chi-square test, P < 0.001). We conclude that ZPP < 150 μmol/mol heme can be used in a new screening strategy for α-thalassemia. [ABSTRACT FROM AUTHOR]
Titel: |
Diagnostic value of zinc protoporphyrin in a screening strategy for α-thalassemia.
|
---|---|
Autor/in / Beteiligte Person: | Sardón Estévez, Nadia ; Herruer, Martinus H. ; Jansen, Ruud ; Bergkamp, Ferry J. M. ; Gorgels, Jozef P. M. C. |
Link: | |
Zeitschrift: | European Journal of Haematology, Jg. 82 (2009-05-01), Heft 5, S. 393-397 |
Veröffentlichung: | 2009 |
Medientyp: | academicJournal |
ISSN: | 0902-4441 (print) |
DOI: | 10.1111/j.1600-0609.2009.01227.x |
Schlagwort: |
|
Sonstiges: |
|