Polyketide Decarboxylative Chain Termination Preceded by O-Sulfonation in Curacin A Biosynthesis.
In: Journal of the American Chemical Society, Jg. 131 (2009-11-11), Heft 44, S. 16033-16035
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Zugriff:
The article discusses the chain termination module of curacin A biosynthesis wherein a putative sulfotransferase (ST) domain is flanked by an acyl carrier protein (ACP) domain and a thioesterase (TE) domain. It states that the marine metabolite curacin A is a mixed-polyketide nonribosomal-peptide with potent anticancer activities. It notes that STs are involved in a broad range of biological processes. It also mentions the biochemical assessment of the ST-TE-mediated chain termination.
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Polyketide Decarboxylative Chain Termination Preceded by O-Sulfonation in Curacin A Biosynthesis.
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Autor/in / Beteiligte Person: | Gu, Liangcai ; Wang, Bo ; Kulkarni, Amol ; Gehret, Jennifer J. ; Lloyd, Kayla R. ; Gerwick, Lena ; Gerwick, William H. ; Wipf, Peter ; Håkansson, Kristina ; Smith, Janet L. ; Sherman, David H. |
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Zeitschrift: | Journal of the American Chemical Society, Jg. 131 (2009-11-11), Heft 44, S. 16033-16035 |
Veröffentlichung: | 2009 |
Medientyp: | academicJournal |
ISSN: | 0002-7863 (print) |
DOI: | 10.1021/ja9071578 |
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