The Effect of Ampicillin and Cholramphenicol Against Haemophilus inflenzae.
In: Pediatrics, Jg. 61 (1978-03-01), Heft 3, S. 406-409
academicJournal
Zugriff:
Abstract. Synergy, determined by isobolograms constructed from the minimal inhibitory concentrations of combinations of ampicillin and chloramphenicol, was observed against six of 13 ampicillin-susceptible Haemophilus influenzae type b isolates and against five of eight ampicillin-resistant strains by using a small inoculum of 10[sup 4] colony forming units (CFU) per milliliter. Synergy occurred against nine of 13 ampicillin-susceptible and against two of eight ampicillin-resistant strains using a large inoculum of 10[sup 7] CFU/ml. When synergy was not observed, additive effects occurred against the remainder of isolates. Additive effects were also observed against single strains of chloramphenicol-resistant, nontypeable H. influenzae and H. parainfluenzae. No antagonism was observed. These data indicate that ampicillin and chloramphenicol may be synergistic against a significant number of H. influenzae strains depending on inoculum size, but the effect is unpredictable for a given isolate. These data support the recommendation that ampicillin and chloramphenicol both be used as initial therapy for patients with suspected bacterial meningitis. Pediatrics 61:406-409, 1978, ampicillin, chloramphenicol, antibiotic synergy, antibiotic antagonism, Haemophilus influenzae. [ABSTRACT FROM AUTHOR]
Titel: |
The Effect of Ampicillin and Cholramphenicol Against Haemophilus inflenzae.
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Autor/in / Beteiligte Person: | Feldman, William E. |
Zeitschrift: | Pediatrics, Jg. 61 (1978-03-01), Heft 3, S. 406-409 |
Veröffentlichung: | 1978 |
Medientyp: | academicJournal |
ISSN: | 0031-4005 (print) |
DOI: | 10.1542/peds.61.3.406 |
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