Is Oral Administration of Chinese Herbal Medicine Effective and Safe as an Adjunctive Therapy for Managing Diabetic Foot Ulcers? A Systematic Review and Meta-Analysis.
In: Journal of Alternative & Complementary Medicine, Jg. 16 (2010-08-01), Heft 8, S. 889-898
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Zugriff:
Objective: This meta-analysis aimed to assess the effectiveness and safety of Chinese herbal medicine (CHM) as an adjunctive method to standard therapy for patients with diabetic foot ulcers (DFU). Methods: Randomized controlled trials (RCTs) of CHM to treat DFU were searched in the following electronic databases: MEDLINE®; EMBASE; Chinese Biomedical Database (CBM); Cochrane Central Register of Controlled Trials (CENTRAL); Allied & Complementary Medicine Resources (AMED); and Cumulative Index to Nursing and Allied Health Literature (CINAHL). Two (2) researchers independently assessed the quality and validity of included trials and extracted outcome data for synthesis. Results: Six (6) trials were included for analysis. Compared to using standard therapy alone, CHM combined with standard therapy significantly increased the number of patients whose ulcers healed (risk ratio [ RR], 0.62, [95% confidence interval (CI), 0.39–0.97]) and number of patients with at least a 30% reduction in the ulcer area ( RR, 0.81 [95%CI, 0.71–0.92]). In addition, the two therapies combined significantly decreased the number of patients without any improvement ( RR, 0.34 [95%CI, 0.21–0.53]). However, with respect to blood flow volume in the dorsal artery of the foot, no significant difference between the two therapies was observed (standardized mean difference, 1.71 [95% CI −1.25–4.67]), but the result favored the CHM combined with standard therapy group. Only 2 of 6 trials reported adverse events, which included nausea, epigastric pain, and dry mouth. Conclusions: CHM may be effective and safe as an adjunctive therapy for treating DFU. However, a firm conclusion could not be reached because of the poor quality of the included trials. Further trials with higher quality are justified. [ABSTRACT FROM AUTHOR]
Titel: |
Is Oral Administration of Chinese Herbal Medicine Effective and Safe as an Adjunctive Therapy for Managing Diabetic Foot Ulcers? A Systematic Review and Meta-Analysis.
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Autor/in / Beteiligte Person: | Chen, Min ; Zheng, Hui ; Yin, Li-Ping ; Xie, Chun-Guang |
Zeitschrift: | Journal of Alternative & Complementary Medicine, Jg. 16 (2010-08-01), Heft 8, S. 889-898 |
Veröffentlichung: | 2010 |
Medientyp: | academicJournal |
ISSN: | 1075-5535 (print) |
DOI: | 10.1089/acm.2009.0470 |
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