Aurothiomalate Inhibits Cyclooxygenase 2, Matrix Metalloproteinase 3, and Interleukin-6 Expression in Chondrocytes by Increasing MAPK Phosphatase 1 Expression and Decreasing p38 Phosphorylation.
In: Arthritis & Rheumatism, Jg. 62 (2010-06-01), Heft 6, S. 1650-1659
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Zugriff:
The article focuses on a study which examined the effects of aurothiomalate on the activity of p38 mitogen-activated protein kinases (MAPK) and on the expression of MAPK pphosphatase 1 (MKP-I), cyclooxygenase 2 (COX-2), atrix metalloproteinase 3 (MMP-3), and interleukin- IL-6) in immortalized murine H4 chondrocytes and in intact human and murine cartilage. Using Western blotting or by enzyme-linked immunosorbent assay, protein expression was examined. Results indicated a novel mechanisms for the antiinflammatory and antierosive actions of aurothiomalate.
Titel: |
Aurothiomalate Inhibits Cyclooxygenase 2, Matrix Metalloproteinase 3, and Interleukin-6 Expression in Chondrocytes by Increasing MAPK Phosphatase 1 Expression and Decreasing p38 Phosphorylation.
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Autor/in / Beteiligte Person: | Nieminen, Riina ; Korhonen, Riku ; Moilanen, Teemu ; Clark, Andrew R. ; Moilanen, Eeva |
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Zeitschrift: | Arthritis & Rheumatism, Jg. 62 (2010-06-01), Heft 6, S. 1650-1659 |
Veröffentlichung: | 2010 |
Medientyp: | academicJournal |
ISSN: | 0004-3591 (print) |
DOI: | 10.1002/art.27409 |
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