Effect of fluorine position on the coordinating ability of fluorosalicylic acids — An experimental study complemented with computations
In: Journal of Inorganic Biochemistry, Jg. 105 (2011), Heft 1, S. 75-83
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Zugriff:
Abstract: The complexation of 3-, 4-, and 6-fluorosalicylic acids (HL) with copper(II) was investigated in aqueous solution by pH-potentiometry combined with UV–visible spectrophotometry, and in 50v/v % water–methanol mixture by the two-dimensional ESR simulation method. Both methods showed the formation of [CuLH−1] and [CuL2H−2]2− of high stabilities, and, at low excess of ligand, the ESR-silent mixed hydroxido complex [Cu2L2H−3]−. Further species were also identified by the two-dimensional ESR simulation method: [CuL]+ in the acidic region, the minor dimer [Cu2L2H−2], and the cis and the trans isomers for [CuL2H−2]2−. The position of the fluorine atom in the aromatic ring had significant effect on the coordination abilities of the ligands, in good correlation with their reported biological activities. It was 3-fluorosalicylic acid, which formed the most stable complexes [CuLH−1] and [CuL2H−2]2−, while the mononuclear complexes with 6-fluorosalicylic acid were found to be the least stable. For the other ligands (including 5-fluorosalicylic acid studied recently), complexes of medium stabilities were formed. For the interpretation of these findings, ab initio and semi-empirical quantum chemical calculations were carried out for the ligand molecules, isolated and surrounded by water molecules, respectively. [ABSTRACT FROM AUTHOR]
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Effect of fluorine position on the coordinating ability of fluorosalicylic acids — An experimental study complemented with computations
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Autor/in / Beteiligte Person: | Szabó-Plánka, Terézia ; Gyurcsik, Béla ; Pálinkó, István ; Nagy, Nóra Veronika ; Rockenbauer, Antal ; Šípoš, Rastislav ; Šima, Jozef ; Melník, Milan |
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Zeitschrift: | Journal of Inorganic Biochemistry, Jg. 105 (2011), Heft 1, S. 75-83 |
Veröffentlichung: | 2011 |
Medientyp: | academicJournal |
ISSN: | 0162-0134 (print) |
DOI: | 10.1016/j.jinorgbio.2010.09.009 |
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