Stability of epidoxorubicin in solid state
In: Journal of Pharmaceutical & Biomedical Analysis, Jg. 54 (2011-03-25), Heft 4, S. 869-872
academicJournal
Zugriff:
Abstract: The influence of temperature and relative air humidity on the stability of epidoxorubicin hydrochloride (EP) was investigated. The degradation of the substance studied was determined: (a) in dry air at 393K, (b) at relative air humidity ∼76% at 333K, 343K, 353K, 363K and 373K, (c) in the relative air humidity range 50–90% at 363K. The degradation of EP in the atmosphere of increased relative air humidity was a first-order reaction relative to substance concentration and in dry, hot air (RH 0%; 393K) is a reversible first-order reaction relative to substance concentration. The dependences ln k = f(1/T) and ln k = f(RH%) were described by the equation: ln k =(35.1±10.9)−(16,250±3823)(1/T) and lnk=(3.79±3.34)×10−2 (RH%)−(12.9±2.4), respectively. The kinetic and thermodynamic parameters of EP degradation were calculated. The parameters of separation were following: LiChrospher RP-18 column, 5μm, 250mm×4mm; mobile phase: the mixture of equal volume of acetonitrile and the solution containing 2.88gl−1 of sodium laurisulfate and 2.25mll−1 of phosphoric acid (V) 85%; flow rate: 1.0mlmin−1; UV detection – 254nm. [ABSTRACT FROM AUTHOR]
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Stability of epidoxorubicin in solid state
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Autor/in / Beteiligte Person: | Sobczak, Agnieszka ; Jelińska, Anna ; Leśniewska, Monika ; Firlej, Artur ; Oszczapowicz, Irena |
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Zeitschrift: | Journal of Pharmaceutical & Biomedical Analysis, Jg. 54 (2011-03-25), Heft 4, S. 869-872 |
Veröffentlichung: | 2011 |
Medientyp: | academicJournal |
ISSN: | 0731-7085 (print) |
DOI: | 10.1016/j.jpba.2010.10.024 |
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