Differential effects of age, cytomegalovirusseropositivity and end-stage renal disease (ESRD) on circulating T lymphocyte subsets.
In: Immunity & Ageing, Jg. 8 (2011), S. 1-10
Online
academicJournal
Zugriff:
The age- and cytomegalovirus (CMV)-seropositivity-related changes in subsets and differentiation of circulating T cells were investigated in end-stage renal disease (ESRD) patients (n = 139) and age-matched healthy individuals. The results show that CMV-seropositivity is associated with expansion of both CD4+ and CD8+ memory T cells which is already observed in young healthy individuals. In addition, CMV-seropositive healthy individuals have a more differentiated memory T cell profile. Only CMV-seropositive healthy individuals showed an age-dependent decrease in CD4+ naïve T cells. The age-related decrease in the number of CD8+ naïve T cells was CMV-independent. In contrast, all ESRD patients showed a profound naïve T-cell lymphopenia at every decade. CMV-seropositivity aggravated the contraction of CD4+ naïve T cells and increased the number of differentiated CD4+ and CD8+ memory T cells. In conclusion, CMV-seropositivity markedly alters the homeostasis of circulating T cells in healthy individuals and aggravates the T cell dysregulation observed in ESRD patients. [ABSTRACT FROM AUTHOR]
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Differential effects of age, cytomegalovirusseropositivity and end-stage renal disease (ESRD) on circulating T lymphocyte subsets.
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Autor/in / Beteiligte Person: | Litjens, Nicolle H. R. ; de Wit, Elly A. ; Betjes, Michiel G. H. |
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Zeitschrift: | Immunity & Ageing, Jg. 8 (2011), S. 1-10 |
Veröffentlichung: | 2011 |
Medientyp: | academicJournal |
ISSN: | 1742-4933 (print) |
DOI: | 10.1186/1742-4933-8-2 |
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