Hippocampal metabolic dysfunction in juvenile myoclonic epilepsy: 3D multivoxel spectroscopy study
In: Journal of the Neurological Sciences, Jg. 305 (2011-06-15), Heft 1/2, S. 139-142
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Zugriff:
Abstract: Purpose: To investigate the metabolic differences in hippocampi of patients with juvenile myoclonic epilepsy (JME) and healthy controls using magnetic resonance spectroscopy (MRS). Methods: A 3D multivoxel SE 135 MRS study on 1.5T scanner of both hippocampi was performed in 17 patients with JME and normal brain MRI and in 19 age and sex matched controls. Three dominant signals were measured: Choline (Cho), Creatine (tCr) and N-Acetylaspartate (NAA) and expressed as ratios of Cho:tCr, NAA:tCr, NAA:Cho and NAA:(Cho+tCr). Metabolite ratios in head, body and tail of each hippocampus in the JME group of patients were compared with ratios from corresponding structures in the control group. Results: We found a significant difference in metabolite ratios of both hippocampi between the JME and the control groups. We detected significant differences of Cho:tCr in the head, NAA:tCr in the head, body and tail, NAA:Cho and NAA:(Cho+tCr) in the body and tail of the left hippocampus, and NAA:Cho and NAA:(Cho+tCr) in the body and tail of the right hippocampus. Discussion: Although not previously recognized as a part of the epileptogenic network, our results suggest that the hippocampus, well recognized as a key player in focal epilepsies, may have a certain role in the pathogenesis of JME. [Copyright &y& Elsevier]
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Hippocampal metabolic dysfunction in juvenile myoclonic epilepsy: 3D multivoxel spectroscopy study
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Autor/in / Beteiligte Person: | Ristić, Aleksandar J. ; Ostojić, Jelena ; Kozić, Duško ; Vojvodić, Nikola M. ; Popović, Ljubica M. ; Janković, Slavko ; Baščarević, Vladimir ; Sokić, Dragoslav V. |
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Zeitschrift: | Journal of the Neurological Sciences, Jg. 305 (2011-06-15), Heft 1/2, S. 139-142 |
Veröffentlichung: | 2011 |
Medientyp: | academicJournal |
ISSN: | 0022-510X (print) |
DOI: | 10.1016/j.jns.2010.12.022 |
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