Onabotulinum toxin A treatment of cervicogenic headache: A randomised, double-blind, placebo-controlled crossover study.
In: Cephalalgia, Jg. 31 (2011-05-01), Heft 7, S. 797-807
Online
academicJournal
Zugriff:
Aims: Preliminary reports regarding injections in the neck of onabotulinum toxin A have been positive in cervicogenic headache (CeH). The aim was to perform the first methodologically rigorous trial.Methods: A randomised, placebo-controlled, patient-, injector- and evaluator-blinded crossover study included 28 adult patients with a long-standing and treatment-resistant CeH. After a baseline period, injections of either onabotulinum toxin A or placebo were given in fixed sites in the neck muscles on the pain side. Second injections were given after ≥8 weeks. Patients were thereafter followed for another 8 weeks. A detailed headache calendar was filled in, and patients were followed with quality-of-life (QoL) questionnaires, algometry and neck mobility measurements.Results: There was no significant difference between verum and placebo in a mixed linear model analysis (p = 0.084) with regard to the primary end-point, reduction of days with moderate to severe headache. Six patients withdrew from the study before the second injections, but an intention-to-treat (ITT) analysis gave a similar result (p = 0.27). There were no significant differences favouring verum in any of the secondary efficacy measures. Side-effects of onabotulinum toxin A were minor and short-lasting.Conclusion: Onabotulinum toxin A in neck muscles does not seem to be beneficial in CeH. [ABSTRACT FROM PUBLISHER]
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Onabotulinum toxin A treatment of cervicogenic headache: A randomised, double-blind, placebo-controlled crossover study.
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Autor/in / Beteiligte Person: | Linde, Mattias ; Hagen, Knut ; Salvesen, Øyvind ; Gravdahl, Gøril Bruvik ; Helde, Grethe ; Stovner, Lars Jacob |
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Zeitschrift: | Cephalalgia, Jg. 31 (2011-05-01), Heft 7, S. 797-807 |
Veröffentlichung: | 2011 |
Medientyp: | academicJournal |
ISSN: | 0333-1024 (print) |
DOI: | 10.1177/0333102411398402 |
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