One-Step, Nonenzymatic Synthesis of O-Acetyl-ADP-ribose and Analogues from NAD and Carboxylates.
In: Journal of Organic Chemistry, Jg. 76 (2011-08-19), Heft 16, S. 6465-6470
academicJournal
Zugriff:
O-Acetyl-ADP-ribose (OAADPR) is a metabolite produced from nicotinamide adenine dinucleotide (NAD) as a product, of sirtuin-mediated protein deacetylation. We present here a simple, one-step, nonenzymatic synthesis of OAADPR from NAD and sodium acetate in acetic add We extended the reaction to other carboxylic adds, demonstrating that the reaction between NAD and nonaqueous carbaxylate buffers produces mixtures of the corresponding 2'- and 3'- carboxylic esters. [ABSTRACT FROM AUTHOR]
| Titel: |
One-Step, Nonenzymatic Synthesis of O-Acetyl-ADP-ribose and Analogues from NAD and Carboxylates.
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| Autor/in / Beteiligte Person: | Szczepankiewicz, Bruce G. ; Koppetsch, Karsten J. ; Perni, Robert B. |
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| Zeitschrift: | Journal of Organic Chemistry, Jg. 76 (2011-08-19), Heft 16, S. 6465-6470 |
| Veröffentlichung: | 2011 |
| Medientyp: | academicJournal |
| ISSN: | 0022-3263 (print) |
| DOI: | 10.1021/jo2008466 |
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