Temporal Variability in Urinary Phthalate Metabolite Excretion Based on Spot, Morning, and 24-h Urine Samples: Considerations for Epidemiological Studies.
In: Environmental Science & Technology, Jg. 47 (2013-01-15), Heft 2, S. 958-967
academicJournal
Zugriff:
Urinary phthalate excretion is used as marker of phthalate exposure in epidemiological studies. Here we examine the reliability of urinary phthalate levels in exposure classification by comparing the inter- and intrasubject variation of urinary phthalate metabolite levels. Thirty-three young healthy men each collected two spot, three first-morning and three 24-h urine samples during a 3-month period. Samples were analyzed for the content of 12 urinary metabolites of 7 different phthalates. Variability was assessed as intraclass correlation coefficients (ICC). For the metabolites of diethyl-, dibutyl-, and butylbenzyl-phthalates moderate ICCs were observed in all three sample types, albeit highest in 24-h urine (0.51- 0.59). For the metabolites of di(2-ethylhexyl) phthalate and di-iso-nonyl phthlates lower ICCs (0.06-0.29) were found. These low ICCs indicate a high risk of misclassification of exposures for these two phthalates in population studies and hence an attenuation of the power to detect possible exposure-outcome associations. The only slightly higher lCCs for 24-h pools compared to first-morning and spot urine samples does not seem to justify the extra effort needed to collect 24-h pools. [ABSTRACT FROM AUTHOR]
Titel: |
Temporal Variability in Urinary Phthalate Metabolite Excretion Based on Spot, Morning, and 24-h Urine Samples: Considerations for Epidemiological Studies.
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Autor/in / Beteiligte Person: | Frederiksen, Hanne ; Kranich, Selma K. ; Jørgensen, Niels ; Taboureau, Olivier ; Petersen, Jørgen H. ; Andersson, Anna-Maria |
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Zeitschrift: | Environmental Science & Technology, Jg. 47 (2013-01-15), Heft 2, S. 958-967 |
Veröffentlichung: | 2013 |
Medientyp: | academicJournal |
ISSN: | 0013-936X (print) |
DOI: | 10.1021/es303640b |
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