Evaluation of Protocol Biopsy Utility 12 Months after Renal Transplantation: A Multicenter Observational Analysis.
In: Journal of Transplantation, 2012, S. 1-9
Online
academicJournal
Zugriff:
The clinical merit of surveillance kidney graft biopsies remains controversial. A retrospective, multicenter analysis evaluated 12-month surveillance biopsies (SB, 154 patients) versus no SB (NSB, 138 patients (11 with diagnostic biopsy)) in patients >18 months posttransplant with estimated GFR (eGFR) ⩾30 mL/min. The primary objective was to describe renal function at 18 months post-transplant in patients with or without SB at month 12. Globally, most recipients in both cohorts were at low immunological risk (<10% of patients with PRA ⩾30%). The immunosuppressive regimen remained unchanged following more than half of SB that exhibited chronic lesions (18/33, 54.5%). Mean (SD) eGFR at month 18 (primary endpoint) was 56 (19) mL/min/1.73m2 with SB and 54 (15) mL/min/1.73m2 with NSB (P = 0.48). In the SB group, slight nonspecific changes were observed in 51 cases, rejection (acute or chronic) in 6 cases, CNI-related toxicity in 15 cases, recurrence of initial disease in two cases, and interstitial fibrosis/tubular atrophy (IF/TA) in 83 cases (71.6%), of which 35 cases (30.2%) were grade II/III lesions. eGFR <50 mL/min/1.73m2 at month 6 predicted IF/TA grade II or III (OR 3.85, 95% CI 1.64, 9.05, P < 0.002). SB at 12 months posttransplant did not prompt significant modification of immunosuppression, and no renal benefit was observed. [ABSTRACT FROM AUTHOR]
Titel: |
Evaluation of Protocol Biopsy Utility 12 Months after Renal Transplantation: A Multicenter Observational Analysis.
|
---|---|
Autor/in / Beteiligte Person: | Moulin, Bruno ; Merville, Pierre ; Renaudin, Karine ; Buob, David ; Ferlicot, Sophie ; Delahousse, Michel ; Dantal, Jacques ; Albano, Laetitia ; Barbet, Christelle ; Mourad, Georges ; Noel, Laure-Hélène |
Link: | |
Zeitschrift: | Journal of Transplantation, 2012, S. 1-9 |
Veröffentlichung: | 2012 |
Medientyp: | academicJournal |
ISSN: | 2090-0007 (print) |
DOI: | 10.1155/2012/781263 |
Schlagwort: |
|
Sonstiges: |
|