Anticancer activity of ruthenium(II) arene complexes bearing 1,2,3,4-tetrahydroisoquinoline amino alcohol ligands.
In: European Journal of Medicinal Chemistry, Jg. 66 (2013-08-01), S. 407-414
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Zugriff:
Abstract: Ruthenium complexes offer potential reduced toxicity compared to current platinum anticancer drugs. 1,2,3,4-tetrahydrisoquinoline amino alcohol ligands were synthesised, characterised and coordinated to an organometallic Ru(II) centre. These complexes were evaluated for activity against the cancer cell lines MCF-7, A549 and MDA-MB-231 as well as for toxicity in the normal cell line MDBK. They were observed to be moderately active against only the MCF-7 cells with the best IC50 value of 34 μM for the cis-diastereomeric complex C4. They also displayed excellent selectivity by being relatively inactive against the normal MDBK cell line with SI values ranging from 2.3 to 7.4. [Copyright &y& Elsevier]
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Anticancer activity of ruthenium(II) arene complexes bearing 1,2,3,4-tetrahydroisoquinoline amino alcohol ligands.
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Autor/in / Beteiligte Person: | Chelopo, Madichaba P. ; Pawar, Sachin A. ; Sokhela, Mxolisi K. ; Govender, Thavendran ; Kruger, Hendrik G. ; Maguire, Glenn E.M. |
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Zeitschrift: | European Journal of Medicinal Chemistry, Jg. 66 (2013-08-01), S. 407-414 |
Veröffentlichung: | 2013 |
Medientyp: | academicJournal |
ISSN: | 0223-5234 (print) |
DOI: | 10.1016/j.ejmech.2013.05.048 |
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