IFN-γ up-regulation of IL-12 beta 2 receptor is associated with experimental autoimmune uveitis susceptible B10.A mice, but not in EAU resistant BALB/c mice
In: Journal of Neuroimmunology, Jg. 137 (2003-04-01), Heft 1/2, S. 154-163
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Zugriff:
IFN-γ production is a hallmark of Th1 response, and IFN-γ has multiple roles in Th1 development, depending on the experimental conditions. In this study, the correlation between IFN-γ and interleukin 12 receptor β2 (IL-12Rβ2) expression was investigated in experimental autoimmune uveitis (EAU) susceptible B10.A and resistant BALB/c mice. B10.A mice expressed high IL-12Rβ2 on T cells either in the disease target eyes or draining lymph node cells (LNC), and its expression correlated with the Th1-type response. In contrast, BALB/c mice only expressed minimal IL-12Rβ2 in draining LNC and had lower Th1-response. B10.A mice produced more IFN-γ and generated a higher number of Th1 cells than that of BALB/c in the draining LNC. Furthermore, IL-12Rβ2 expression and STAT4 signaling were inhibited by anti-IFN-γ mAb in the cultured draining LNC from B10.A mice, but enhanced by adding exogenous IFN-γ in the cultured cells from BALB/c mice. The IL-12Rβ2 expression on Th1 cells from draining LNC was increased in the presence of IL-12 and IFN-γ. In conclusion, IFN-γ production correlated with IL-12Rβ2 expression on Th1-cells and IFN-γ had a potential to regulate IL-12Rβ2 expression in vivo. This regulatory mechanism might be involved in EAU induction. [Copyright &y& Elsevier]
Titel: |
IFN-γ up-regulation of IL-12 beta 2 receptor is associated with experimental autoimmune uveitis susceptible B10.A mice, but not in EAU resistant BALB/c mice
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Autor/in / Beteiligte Person: | Wu, Yadi ; Lin, Ying ; Hou, Wanqiu ; Wang, Yanping ; Sun, Bing |
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Zeitschrift: | Journal of Neuroimmunology, Jg. 137 (2003-04-01), Heft 1/2, S. 154-163 |
Veröffentlichung: | 2003 |
Medientyp: | academicJournal |
ISSN: | 0165-5728 (print) |
DOI: | 10.1016/S0165-5728(03)00071-7 |
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