Association between structural and functional corticospinal involvement in amyotrophic lateral sclerosis assessed by diffusion tensor MRI and triple stimulation technique.
In: Muscle & Nerve, Jg. 49 (2014-04-01), Heft 4, S. 551-557
Online
academicJournal
Zugriff:
ABSTRACT Introduction: We investigated the functional and structural integrity of the corticospinal tract (CST) using diffusion tensor imaging (DTI) and the triple stimulation technique (TST) in patients with amyotrophic lateral sclerosis (ALS). Methods: Fourteen patients with ALS, 13 healthy controls (HCs), and 6 patients with lower motor neuron (LMN) syndrome underwent DTI and TST. Results: The mean diffusivity was higher in ALS patients than HCs ( P < 0.01). The TST ratio was lower in ALS patients compared with HCs ( P < 0.001) and in LMN patients compared with HCs ( P < 0.05). The increase in the mean diffusivity was correlated with the decrease in the TST ratio ( P < 0.01). Conclusions: Significant correlations exist between the DTI and TST results, indicating both structural and functional involvement of the CST in patients with ALS. Muscle Nerve 49:551-557, 2014 [ABSTRACT FROM AUTHOR]
Titel: |
Association between structural and functional corticospinal involvement in amyotrophic lateral sclerosis assessed by diffusion tensor MRI and triple stimulation technique.
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Autor/in / Beteiligte Person: | Grapperon, Aude‐Marie ; Verschueren, Annie ; Duclos, Yann ; Confort‐Gouny, Sylviane ; Soulier, Elisabeth ; Loundou, Anderson D. ; Guye, Maxime ; Cozzone, Patrick J. ; Pouget, Jean ; Ranjeva, Jean‐Philippe ; Attarian, Shahram |
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Zeitschrift: | Muscle & Nerve, Jg. 49 (2014-04-01), Heft 4, S. 551-557 |
Veröffentlichung: | 2014 |
Medientyp: | academicJournal |
ISSN: | 0148-639X (print) |
DOI: | 10.1002/mus.23957 |
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