Physical exercise ameliorates the reduction of neural stem cell, cell proliferation and neuroblast differentiation in senescent mice induced by D-galactose.
In: BMC Neuroscience, Jg. 15 (2014-11-01), Heft 1, S. 1-25
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Zugriff:
Background Aging negatively affects adult hippocampal neurogenesis, and exercise attenuates the age-related reduction in adult hippocampal neurogenesis. In the present study, we used senescent mice induced by D-galactose to examine neural stem cells, cell proliferation, and neuronal differentiation with or without exercise treatment. D-galactose (100 mg/kg) was injected to six-week-old C57BL/6 J mice for 6 weeks to induce the senescent model. During these periods, the animals were placed on a treadmill and acclimated to exercise for 1 week. Then treadmill running was conducted for 1 h/day for 5 consecutive days at 10-12 m/min for 5 weeks. Results Body weight and food intake did not change significantly after D-galactose administration with/without treadmill exercise, although body weight and food intake was highest after treadmill exercise in adult animals and lowest after treadmill exercise in D-galactose-induced senescent model animals. D-galactose treatment significantly decreased the number of nestin (a neural stem cell marker), Ki67 (a cell proliferation marker), and doublecortin (DCX, a differentiating neuroblast marker) positive cells compared to those in the control group. In contrast, treadmill exercise significantly increased Ki67- and DCX-positive cell numbers in both the vehicle- and D-galactose treated groups. In addition, phosphorylated cAMP-response element binding protein (pCREB) and brain derived neurotrophic factor (BDNF) was significantly decreased in the D-galactose treated group, whereas exercise increased their expression in the subgranular zone of the dentate gyrus in both the vehicle- and D-galactose treated groups. Conclusion These results suggest that treadmill exercise attenuates the D-galactose-induced reduction in neural stem cells, cell proliferation, and neuronal differentiation by enhancing the expression of pCREB and BDNF in the dentate gyrus of the hippocampus. [ABSTRACT FROM AUTHOR]
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Physical exercise ameliorates the reduction of neural stem cell, cell proliferation and neuroblast differentiation in senescent mice induced by D-galactose.
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Autor/in / Beteiligte Person: | Sung Min Nam ; Jong Whi Kim ; Dae Young Yoo ; Hee Sun Yim ; Dae Won Kim ; Jung Hoon Choi ; Kim, Woosuk ; Hyo Young Jung ; Won, Moo-Ho ; In Koo Hwang ; Je Kyung Seong ; Yeo Sung Yoon |
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Zeitschrift: | BMC Neuroscience, Jg. 15 (2014-11-01), Heft 1, S. 1-25 |
Veröffentlichung: | 2014 |
Medientyp: | academicJournal |
ISSN: | 1471-2202 (print) |
DOI: | 10.1186/s12868-014-0116-4 |
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