Preprodynorphin-like immunoreactivity in medullary dorsal horn neurons projecting to the thalamic regions in the rat.
In: Neuroscience letters, Jg. 264 (1999-04-02), Heft 1-3, S. 13-6
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Zugriff:
Preprodynorphin (PPD)-like immunoreactive (-LI) neuronal cell bodies in the trigeminal sensory nuclear complex of the rat were found in laminae I and II of the medullary dorsal horn (MDH; caudal spinal trigeminal nucleus) and the paratrigeminal nucleus. A PPD immunofluorescence histochemistry combined with a fluorescence retrograde tract-tracing method revealed that some of the PPD-LI neurons in the MDH and paratrigeminal nucleus projected to the thalamic regions. Nociceptive nature of the PPD-LI MDH neurons projecting to the thalamic regions was also demonstrated by a triple labeling method, using the technique of the noxious stimulus-evoked expression of the immediate-early gene, c-fos. In the rats which were subcutaneously injected with formalin into the upper and lower lips, c-fos protein (Fos) was found in PPD-LI neurons which were labeled with a retrograde tracer injected into the thalamic regions.
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Preprodynorphin-like immunoreactivity in medullary dorsal horn neurons projecting to the thalamic regions in the rat.
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Autor/in / Beteiligte Person: | Li, JL ; Li, YQ ; Kaneko, T ; Mizuno, N |
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Zeitschrift: | Neuroscience letters, Jg. 264 (1999-04-02), Heft 1-3, S. 13-6 |
Veröffentlichung: | Limerick : Elsevier Scientific Publishers Ireland ; <i>Original Publication</i>: Amsterdam, Elsevier/North-Holland., 1999 |
Medientyp: | academicJournal |
ISSN: | 0304-3940 (print) |
DOI: | 10.1016/s0304-3940(99)00132-9 |
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