[Susceptibility to fluconazole and itraconazole in isolates of Candida spp. from HIV-positive and HIV-negative patients].
In: Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia, Jg. 13 (2000-03-01), Heft 1, S. 60-3
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Zugriff:
We studied the possible differences in the pattern of susceptibility to fluconazole and itraconazole in 393 isolates of Candida spp. from the oral cavity of HIV-positive patients and 102 isolates from HIV-negative patients with candidemia or candiduria. We used the broth microdilution method according to the NCCLS guidelines. We observed a decrease in the susceptibility to fluconazole in the group of HIV-positive patients in comparison to those who were HIV negative, especially in Candida albicans (MIC(90) 32 mg/l vs. 1 mg/l and Candida glabrata (MIC(90) 64 mg/l vs. 16 mg/l). Furthermore, we did not find any resistant strains in the HIV-negative group. For itraconazole, the MIC(90) was two dilutions greater in the HIV-positive patients, except for C. albicans, which had a much higher MIC(90) (4 mg/l vs. 0.12 mg/.). Therefore, the decrease in the susceptibility of Candida spp. in the HIV-positive patients must be taken into account when establishing a specific antifungal therapy.
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[Susceptibility to fluconazole and itraconazole in isolates of Candida spp. from HIV-positive and HIV-negative patients].
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Autor/in / Beteiligte Person: | Bernal, S ; Gutiérrez, MJ ; Serrano, MC ; Chávez, M ; Valverde, A ; Quindós, G ; Mazuelos, EM |
Zeitschrift: | Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia, Jg. 13 (2000-03-01), Heft 1, S. 60-3 |
Veröffentlichung: | [Barcelona] : Sociedad Española de Quimioterapia ; <i>Original Publication</i>: Barcelona : J.R. Prous, S.A., [1988-, 2000 |
Medientyp: | academicJournal |
ISSN: | 0214-3429 (print) |
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