Chemotactic activity of CXC chemokines interleukin-8, growth-related oncogene-alpha, and epithelial cell-derived neutrophil-activating protein-78 in urine of patients with urosepsis.
In: The Journal of infectious diseases, Jg. 182 (2000-12-01), Heft 6, S. 1731-7
Online
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Zugriff:
CXC chemokines are chemotactic cytokines that specifically act on neutrophils. To obtain insight into the extent of local production of CXC chemokines during acute pyelonephritis, interleukin (IL)-8, growth-related oncogene (GRO)-alpha, and epithelial cell-derived neutrophil-activating protein (ENA)-78 were measured in urine and plasma samples from patients with culture-proven urosepsis (n=33), healthy human control subjects with sterile urine (n=31), and human volunteers intravenously injected with endotoxin (n=11). Patients had profoundly elevated urine concentrations of chemokines with no (GRO-alpha and ENA-78) or little (IL-8) elevation in plasma. Endotoxin-challenged subjects demonstrated transient increases in plasma chemokine concentrations, with no (GRO-alpha) or little (IL-8 and ENA-78) elevation in urine. Urine from patients exerted chemotactic activity toward neutrophils, which was partially inhibited by neutralizing antibodies against IL-8, GRO-alpha, or ENA-78. During urosepsis, CXC chemokines are predominantly produced within the urinary tract, where they are involved in the recruitment of neutrophils to the urinary compartment.
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Chemotactic activity of CXC chemokines interleukin-8, growth-related oncogene-alpha, and epithelial cell-derived neutrophil-activating protein-78 in urine of patients with urosepsis.
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Autor/in / Beteiligte Person: | Olszyna, DP ; Opal, SM ; Prins, JM ; Horn, DL ; Speelman, P ; van Deventer SJ ; van der Poll T |
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Zeitschrift: | The Journal of infectious diseases, Jg. 182 (2000-12-01), Heft 6, S. 1731-7 |
Veröffentlichung: | Jan. 2011- : Oxford : Oxford University Press ; <i>Original Publication</i>: 1904-2010 : Chicago, IL : University of Chicago Press, 2000 |
Medientyp: | academicJournal |
ISSN: | 0022-1899 (print) |
DOI: | 10.1086/317603 |
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