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The BvgAS signal transduction system controls the expression of at least three distinct phenotypic phases that lie along a continuum of gene expression states. The Bvg+ phase is characterized by the expression of adhesins and toxins, whereas the Bvg- phase is characterized by motility in Bordetella bronchiseptica and the expression of vrg loci in Bordetella pertussis. The Bvg-intermediate (Bvgi) phase is characterized by the absence of Bvg-repressed phenotypes, the expression of some, but not all, Bvg-activated virulence factors and the presence of a recently discovered set of antigens and phenotypes that are unique to this phase. We report here the transcriptional regulation of bipA, the first-identified Bvgi phase gene. We have mapped the bipA promoter and identified numerous BvgA binding sites in the transcriptional control region. Based on these data, we present a model in which phase-dependent expression of bipA results from the spatial distribution and relative affinities of multiple BvgA binding sites relative to the start site of transcription.

Titel:	Diversity in the Bordetella virulence regulon: transcriptional control of a Bvg-intermediate phase gene.
Autor/in / Beteiligte Person:	Deora, R ; Bootsma, HJ ; Miller, JF ; Cotter, PA
Link:	Full Text Finder (Volltext)
Zeitschrift:	Molecular microbiology, Jg. 40 (2001-05-01), Heft 3, S. 669-83
Veröffentlichung:	Oxford, OX ; Boston, MA : Blackwell Scientific Publications, c1987-, 2001
Medientyp:	academicJournal
ISSN:	0950-382X (print)
DOI:	10.1046/j.1365-2958.2001.02415.x
Schlagwort:	Adenylate Cyclase Toxin Adhesins, Bacterial genetics Bacterial Proteins genetics Base Sequence Binding Sites Bordetella pathogenicity DNA, Bacterial Deoxyribonuclease I Escherichia coli Flagellin genetics Gene Expression Profiling Hemagglutinins genetics Lac Operon Molecular Sequence Data Promoter Regions, Genetic Protein Precursors genetics Signal Transduction Transcription Factors genetics Transcription, Genetic Virulence Bacterial Outer Membrane Proteins genetics Bacterial Proteins metabolism Bordetella genetics Escherichia coli Proteins Gene Expression Regulation, Bacterial Regulon Transcription Factors metabolism Virulence Factors, Bordetella
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. Language: English [Mol Microbiol] 2001 May; Vol. 40 (3), pp. 669-83. MeSH Terms: Escherichia coli Proteins* ; Gene Expression Regulation, Bacterial* ; Regulon* ; Virulence Factors, Bordetella* ; Bacterial Outer Membrane Proteins / genetics ; Bacterial Proteins / metabolism ; Bordetella / genetics ; Transcription Factors / metabolism ; Adenylate Cyclase Toxin ; Adhesins, Bacterial / genetics ; Bacterial Proteins / genetics ; Base Sequence ; Binding Sites ; Bordetella / pathogenicity ; DNA, Bacterial ; Deoxyribonuclease I ; Escherichia coli ; Flagellin / genetics ; Gene Expression Profiling ; Hemagglutinins / genetics ; Lac Operon ; Molecular Sequence Data ; Promoter Regions, Genetic ; Protein Precursors / genetics ; Signal Transduction ; Transcription Factors / genetics ; Transcription, Genetic ; Virulence Grant Information: A138417 United States PHS HHS; A143986 United States PHS HHS; T32A107323 United States PHS HHS Substance Nomenclature: 0 (Adenylate Cyclase Toxin) ; 0 (Adhesins, Bacterial) ; 0 (Bacterial Outer Membrane Proteins) ; 0 (Bacterial Proteins) ; 0 (BipA protein, Bordetella) ; 0 (BvgA protein, Bacteria) ; 0 (DNA, Bacterial) ; 0 (Escherichia coli Proteins) ; 0 (EvgA protein, E coli) ; 0 (Hemagglutinins) ; 0 (Protein Precursors) ; 0 (Transcription Factors) ; 0 (Virulence Factors, Bordetella) ; 0 (bvgS protein, Bordetella pertussis) ; 0 (filamentous hemagglutinin adhesin, Bordetella pertussis) ; 12777-81-0 (Flagellin) ; 133606-66-3 (flaA protein, bacteria) ; EC 3.1.21.1 (Deoxyribonuclease I) Entry Date(s): Date Created: 20010522 Date Completed: 20010927 Latest Revision: 20190725 Update Code: 20240513

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Diversity in the Bordetella virulence regulon: transcriptional control of a Bvg-intermediate phase gene.