Dbl family guanine nucleotide exchange factors.
In: Trends in biochemical sciences, Jg. 26 (2001-12-01), Heft 12, S. 724-32
academicJournal
Zugriff:
The Dbl family of guanine nucleotide exchange factors are multifunctional molecules that transduce diverse intracellular signals leading to the activation of Rho GTPases. The tandem Dbl-homology and pleckstrin-homology domains shared by all members of this family represent the structural module responsible for catalyzing the GDP-GTP exchange reaction of Rho proteins. Recent progress in genomic, genetic, structural and biochemical studies has implicated Dbl family members in diverse biological processes, including growth and development, skeletal muscle formation, neuronal axon guidance and tissue organization. The detailed pictures of their autoregulation, agonist-controlled activation and mechanism of interaction with Rho GTPase substrates, have begun to emerge.
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Dbl family guanine nucleotide exchange factors.
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Autor/in / Beteiligte Person: | Zheng, Y |
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Zeitschrift: | Trends in biochemical sciences, Jg. 26 (2001-12-01), Heft 12, S. 724-32 |
Veröffentlichung: | Cambridge (Eng) : Elsevier Trends Journals ; <i>Original Publication</i>: Amsterdam, Published for the International Union of Biochemistry by Elsevier Scientific Pub. Co., 2001 |
Medientyp: | academicJournal |
ISSN: | 0968-0004 (print) |
DOI: | 10.1016/s0968-0004(01)01973-9 |
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