A comparison between ischemic preconditioning, intermittent cross-clamp fibrillation and cold crystalloid cardioplegia for myocardial protection during coronary artery bypass graft surgery.
In: Cardiovascular surgery (London, England), Jg. 10 (2002-06-01), Heft 3, S. 251-5
academicJournal
Zugriff:
The aim of this study was to compare ischemic preconditioning (IPC) with two established methods of myocardial protection, namely cold crystalloid cardioplegia and intermittent cross-clamp fibrillation (ICCF), in coronary artery bypass graft (CABG) surgery. This was a prospective randomised study. Thirty CABG patients were randomised to receive: (a) St Thomas' cardioplegia solution no. 2; (b) ICCF; or (c) IPC (two 3-min periods of ischemia with 2-min of reperfusion). Surgery was performed under standardised conditions by one surgeon (WBP). The primary endpoint was cardiac troponin T release during the first 72 h after surgery. Mean troponin T at 72 h was significantly lower in the IPC group (0.5 microg/l; p=0.05, ANOVA) compared with the cardioplegia and ICCF groups (2.1 and 1.3 microg/l respectively). This suggests that ischemic preconditioning is superior at limiting myocardial necrosis during CABG, but there is no difference between cold crystalloid cardioplegia and intermittent cross-clamp fibrillation.
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A comparison between ischemic preconditioning, intermittent cross-clamp fibrillation and cold crystalloid cardioplegia for myocardial protection during coronary artery bypass graft surgery.
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Autor/in / Beteiligte Person: | Teoh, LK ; Grant, R ; Hulf, JA ; Pugsley, WB ; Yellon, DM |
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Zeitschrift: | Cardiovascular surgery (London, England), Jg. 10 (2002-06-01), Heft 3, S. 251-5 |
Veröffentlichung: | Exeter : Elsevier Ltd ; <i>Original Publication</i>: London : Butterworth-Heinemann, c1993-c2003., 2002 |
Medientyp: | academicJournal |
ISSN: | 0967-2109 (print) |
DOI: | 10.1016/s0967-2109(02)00007-8 |
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