A comparison between ischemic preconditioning, intermittent cross-clamp fibrillation and cold crystalloid cardioplegia for myocardial protection during coronary artery bypass graft surgery.

Teoh, LK ; Grant, R ; et al.

In: Cardiovascular surgery (London, England), Jg. 10 (2002-06-01), Heft 3, S. 251-5

academicJournal

The aim of this study was to compare ischemic preconditioning (IPC) with two established methods of myocardial protection, namely cold crystalloid cardioplegia and intermittent cross-clamp fibrillation (ICCF), in coronary artery bypass graft (CABG) surgery. This was a prospective randomised study. Thirty CABG patients were randomised to receive: (a) St Thomas' cardioplegia solution no. 2; (b) ICCF; or (c) IPC (two 3-min periods of ischemia with 2-min of reperfusion). Surgery was performed under standardised conditions by one surgeon (WBP). The primary endpoint was cardiac troponin T release during the first 72 h after surgery. Mean troponin T at 72 h was significantly lower in the IPC group (0.5 microg/l; p=0.05, ANOVA) compared with the cardioplegia and ICCF groups (2.1 and 1.3 microg/l respectively). This suggests that ischemic preconditioning is superior at limiting myocardial necrosis during CABG, but there is no difference between cold crystalloid cardioplegia and intermittent cross-clamp fibrillation.

Titel:	A comparison between ischemic preconditioning, intermittent cross-clamp fibrillation and cold crystalloid cardioplegia for myocardial protection during coronary artery bypass graft surgery.
Autor/in / Beteiligte Person:	Teoh, LK ; Grant, R ; Hulf, JA ; Pugsley, WB ; Yellon, DM
Link:	E-Journal im Bestand der UB Hagen?
Zeitschrift:	Cardiovascular surgery (London, England), Jg. 10 (2002-06-01), Heft 3, S. 251-5
Veröffentlichung:	Exeter : Elsevier Ltd ; <i>Original Publication</i>: London : Butterworth-Heinemann, c1993-c2003., 2002
Medientyp:	academicJournal
ISSN:	0967-2109 (print)
DOI:	10.1016/s0967-2109(02)00007-8
Schlagwort:	Aorta, Thoracic Arrhythmias, Cardiac diagnosis Arrhythmias, Cardiac physiopathology Cardioplegic Solutions administration & dosage Constriction Electrocardiography Hemodynamics Humans Prospective Studies Treatment Outcome Troponin T blood Ventricular Fibrillation Coronary Artery Bypass methods Heart Arrest, Induced methods Ischemic Preconditioning, Myocardial methods
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Language: English [Cardiovasc Surg] 2002 Jun; Vol. 10 (3), pp. 251-5. MeSH Terms: Coronary Artery Bypass / methods ; Heart Arrest, Induced / methods ; Ischemic Preconditioning, Myocardial / *methods ; Aorta, Thoracic ; Arrhythmias, Cardiac / diagnosis ; Arrhythmias, Cardiac / physiopathology ; Cardioplegic Solutions / administration & dosage ; Constriction ; Electrocardiography ; Hemodynamics ; Humans ; Prospective Studies ; Treatment Outcome ; Troponin T / blood ; Ventricular Fibrillation Substance Nomenclature: 0 (Cardioplegic Solutions) ; 0 (Troponin T) Entry Date(s): Date Created: 20020605 Date Completed: 20020919 Latest Revision: 20191025 Update Code: 20240513

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