Transactivation of the human endogenous retrovirus K long terminal repeat by herpes simplex virus type 1 immediate early protein 0.
In: Virus research, Jg. 86 (2002-06-01), Heft 1-2, S. 93-100
academicJournal
Zugriff:
We found that LTR-directed transcription of the human endogenous retrovirus K can be induced by HSV-1 infection. The effect was mediated by the action of a HSV-1 immediate early protein, ICP0 and required the AP-1 binding site present on the HERV-K LTR. In addition, ICP0 could up-regulate AP-1 activity, suggesting that ICP0 increases transcription of HERV-K through AP-1 site. This effect might be important to understand both HERV-K- and HSV-1-mediated pathogenesis because HERV-K LTR represents an important class of retrotranspositional mutagens and also could provide a new regulatory element for the linked DNA sequences.
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Transactivation of the human endogenous retrovirus K long terminal repeat by herpes simplex virus type 1 immediate early protein 0.
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Autor/in / Beteiligte Person: | Kwun, HJ ; Han, HJ ; Lee, WJ ; Kim, HS ; Jang, KL |
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Zeitschrift: | Virus research, Jg. 86 (2002-06-01), Heft 1-2, S. 93-100 |
Veröffentlichung: | Amsterdam : Elsevier Science, c1984-, 2002 |
Medientyp: | academicJournal |
ISSN: | 0168-1702 (print) |
DOI: | 10.1016/s0168-1702(02)00058-8 |
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