Synthetic peptides for study of human immunodeficiency virus infection.

Dettin, M ; Scarinci, C ; et al.

In: Applied biochemistry and biotechnology, Jg. 102-103 (2002-07-01), Heft 1-6, S. 41-7

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Zugriff:

The formation of a complex among gp120, CD4, and CCR5/CXCR4 represents a key step in human immunodeficiency virus (HIV) infection. The use of synthetic peptides reproducing sequences of these surface proteins has increased knowledge about the interactions that determine the penetration of HIV viruses into target cells. The final aim of such investigations is the design of molecules able to inhibit the initial step of infection and the development of high-sensitivity in vitro assays for detection of HIV. In particular, the studies presented herein concern the role of the gp120 V3 loop in the CD4 binding, the importance of the N-terminal sequence of HIV-coreceptor CCR5, the sequences patterned on CXCR4 natural ligand (stromal-derived factor 1 [SDF-1]) as inhibitory peptides, and the importance of substrate secondary structure in determining the enzymatic processing of gp120 precursor (gp160).

Titel:	Synthetic peptides for study of human immunodeficiency virus infection.
Autor/in / Beteiligte Person:	Dettin, M ; Scarinci, C ; Pasquato, A ; Di Bello, C
Link:	View record at Springer (Volltext)
Zeitschrift:	Applied biochemistry and biotechnology, Jg. 102-103 (2002-07-01), Heft 1-6, S. 41-7
Veröffentlichung:	Clifton, N.J. : Humana Press, c1981-, 2002
Medientyp:	academicJournal
ISSN:	0273-2289 (print)
DOI:	10.1385/abab:102-103:1-6:041
Schlagwort:	Amino Acid Sequence CD4 Antigens metabolism Chemokine CXCL12 Chemokines, CXC chemistry Chemokines, CXC genetics Cytokines chemistry Cytokines genetics Drug Design HIV Envelope Protein gp120 chemistry HIV Envelope Protein gp120 genetics HIV Infections metabolism HIV-1 genetics HIV-1 metabolism Humans Molecular Sequence Data Point Mutation Receptors, CCR5 chemistry Receptors, CCR5 genetics Receptors, CXCR4 chemistry Receptors, CXCR4 genetics Recombinant Proteins metabolism Tumor Cells, Cultured Chemokines, CXC metabolism Cytokines metabolism HIV Envelope Protein gp120 metabolism HIV Infections virology Peptide Fragments metabolism Receptors, CCR5 metabolism Receptors, CXCR4 metabolism
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Review Language: English [Appl Biochem Biotechnol] 2002 Jul-Dec; Vol. 102-103 (1-6), pp. 41-7. MeSH Terms: Chemokines, CXC / metabolism ; Cytokines / metabolism ; HIV Envelope Protein gp120 / metabolism ; HIV Infections / virology ; Peptide Fragments / metabolism ; Receptors, CCR5 / metabolism ; Receptors, CXCR4 / *metabolism ; Amino Acid Sequence ; CD4 Antigens / metabolism ; Chemokine CXCL12 ; Chemokines, CXC / chemistry ; Chemokines, CXC / genetics ; Cytokines / chemistry ; Cytokines / genetics ; Drug Design ; HIV Envelope Protein gp120 / chemistry ; HIV Envelope Protein gp120 / genetics ; HIV Infections / metabolism ; HIV-1 / genetics ; HIV-1 / metabolism ; Humans ; Molecular Sequence Data ; Point Mutation ; Receptors, CCR5 / chemistry ; Receptors, CCR5 / genetics ; Receptors, CXCR4 / chemistry ; Receptors, CXCR4 / genetics ; Recombinant Proteins / metabolism ; Tumor Cells, Cultured Number of References: 18 Substance Nomenclature: 0 (CD4 Antigens) ; 0 (CXCL12 protein, human) ; 0 (Chemokine CXCL12) ; 0 (Chemokines, CXC) ; 0 (Cytokines) ; 0 (HIV Envelope Protein gp120) ; 0 (Peptide Fragments) ; 0 (Receptors, CCR5) ; 0 (Receptors, CXCR4) ; 0 (Recombinant Proteins) Entry Date(s): Date Created: 20021025 Date Completed: 20030521 Latest Revision: 20190910 Update Code: 20231215

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