Interferon-gamma enhances the pulmonary CXC chemokine response to intratracheal lipopolysaccharide challenge.

Zhang, P ; Quinton, LJ ; et al.

In: The Journal of infectious diseases, Jg. 187 (2003), Heft 1, S. 62-9

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CXC chemokines are major chemoattractants for pulmonary polymorphonuclear leukocyte (PMNL) recruitment. To study the effects of interferon (IFN)-gamma on the pulmonary chemokine response to lipopolysaccharide (LPS) challenge, rats were treated with intratracheal IFN-gamma (1x10(5) U/rat) 24 h before an intratracheal LPS (100 microg/rat) challenge. Intratracheal LPS caused significant increases in both cytokine-induced neutrophil chemoattractant (CINC) and macrophage inflammatory protein-2 in bronchoalveolar lavage (BAL) fluid and pulmonary PMNL recruitment. IFN-gamma enhanced these responses. IFN-gamma also increased LPS-induced tumor necrosis factor (TNF)-alpha in BAL fluid. LPS-induced TNF-alpha and CINC mRNA expression in alveolar macrophages was increased by IFN-gamma. CD11b/c and CD18 expression on circulating PMNLs was not affected by IFN-gamma, nor was the chemotaxis of these cells. IFN-gamma increases the pulmonary CXC chemokine response, which may serve as one mechanism underlying enhanced PMNL delivery into the lung.

Titel:	Interferon-gamma enhances the pulmonary CXC chemokine response to intratracheal lipopolysaccharide challenge.
Autor/in / Beteiligte Person:	Zhang, P ; Quinton, LJ ; Bagby, GJ ; Summer, WR ; Nelson, S
Link:	Full Text Finder (Volltext)
Zeitschrift:	The Journal of infectious diseases, Jg. 187 (2003), Heft 1, S. 62-9
Veröffentlichung:	Jan. 2011- : Oxford : Oxford University Press ; <i>Original Publication</i>: 1904-2010 : Chicago, IL : University of Chicago Press, 2003
Medientyp:	academicJournal
ISSN:	0022-1899 (print)
DOI:	10.1086/346027
Schlagwort:	Animals CD18 Antigens biosynthesis Chemokine CXCL2 Chemokines genetics Chemotactic Factors genetics Injections, Spinal Intercellular Signaling Peptides and Proteins genetics Lipopolysaccharides administration & dosage Male Neutrophils physiology RNA, Messenger Rats Rats, Sprague-Dawley Tumor Necrosis Factor-alpha biosynthesis Tumor Necrosis Factor-alpha genetics Chemokines biosynthesis Chemokines, CXC Chemotactic Factors biosynthesis Intercellular Signaling Peptides and Proteins biosynthesis Interferon-gamma pharmacology Lipopolysaccharides pharmacology Lung immunology Monokines biosynthesis
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. Language: English [J Infect Dis] 2003 Jan 01; Vol. 187 (1), pp. 62-9. <i>Date of Electronic Publication: </i>2002 Dec 13. MeSH Terms: Chemokines, CXC* ; Chemokines / biosynthesis ; Chemotactic Factors / biosynthesis ; Intercellular Signaling Peptides and Proteins / biosynthesis ; Interferon-gamma / pharmacology ; Lipopolysaccharides / pharmacology ; Lung / immunology ; Monokines / *biosynthesis ; Animals ; CD18 Antigens / biosynthesis ; Chemokine CXCL2 ; Chemokines / genetics ; Chemotactic Factors / genetics ; Injections, Spinal ; Intercellular Signaling Peptides and Proteins / genetics ; Lipopolysaccharides / administration & dosage ; Male ; Neutrophils / physiology ; RNA, Messenger ; Rats ; Rats, Sprague-Dawley ; Tumor Necrosis Factor-alpha / biosynthesis ; Tumor Necrosis Factor-alpha / genetics Grant Information: AA09803 United States AA NIAAA NIH HHS Substance Nomenclature: 0 (CD18 Antigens) ; 0 (Chemokine CXCL2) ; 0 (Chemokines) ; 0 (Chemokines, CXC) ; 0 (Chemotactic Factors) ; 0 (Cxcl2 protein, rat) ; 0 (Intercellular Signaling Peptides and Proteins) ; 0 (Lipopolysaccharides) ; 0 (Monokines) ; 0 (RNA, Messenger) ; 0 (Tumor Necrosis Factor-alpha) ; 82115-62-6 (Interferon-gamma) Entry Date(s): Date Created: 20030101 Date Completed: 20030130 Latest Revision: 20171116 Update Code: 20240513

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