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Low and high frequency electro-acupuncture (EA) stimulation was used in rats that had been lesioned by medial forebrain bundle transection. Behavioral tests showed that both low and high frequency EA stimulation significantly reduced the amphetamine-induced rotation 2 weeks after the lesion but only high frequency EA improved the rotational behavior at 4 weeks. Analysis of the dopamine content in the striatum did not show any significant change after EA. In situ hybridization showed that high frequency EA stimulation up-regulated the glial cell line-derived neurotrophic factor (GDNF) mRNA in both sides of the globus pallidus, while low frequency EA only affected the unlesioned side. It suggests that the retrograde nourishment of GDNF to the dopaminergic neurons and the balanced activity of different nuclei in the basal ganglia circuit after EA may contribute to the behavioral improvement in these rats, which might be the factors that underlie the effectiveness of EA in the treatment of Parkinson's disease.

Titel:	Electro-acupuncture improves behavior and upregulates GDNF mRNA in MFB transected rats.
Autor/in / Beteiligte Person:	Liang, XB ; Luo, Y ; Liu, XY ; Lu, J ; Li, FQ ; Wang, Q ; Wang, XM ; Han, JS
Link:	Full Text Finder (Volltext)
Zeitschrift:	Neuroreport, Jg. 14 (2003-06-11), Heft 8, S. 1177-81
Veröffentlichung:	London, England : Lippincott Williams & Wilkins ; <i>Original Publication</i>: Oxford, UK : Rapid Communications of Oxford Ltd., [1990-, 2003
Medientyp:	academicJournal
ISSN:	0959-4965 (print)
DOI:	10.1097/00001756-200306110-00015
Schlagwort:	Amphetamines toxicity Animals Behavior, Animal drug effects Cell Count methods Central Nervous System Stimulants toxicity Corpus Striatum anatomy & histology Corpus Striatum metabolism Disease Models, Animal Dopamine metabolism Female Functional Laterality Glial Cell Line-Derived Neurotrophic Factor In Situ Hybridization In Vitro Techniques Medial Forebrain Bundle injuries Nerve Growth Factors genetics RNA, Messenger biosynthesis Rats Rats, Wistar Rotation Up-Regulation genetics Behavior, Animal physiology Electroacupuncture Medial Forebrain Bundle metabolism Nerve Growth Factors metabolism
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Language: English [Neuroreport] 2003 Jun 11; Vol. 14 (8), pp. 1177-81. MeSH Terms: Electroacupuncture* ; Behavior, Animal / physiology ; Medial Forebrain Bundle / metabolism ; Nerve Growth Factors / *metabolism ; Amphetamines / toxicity ; Animals ; Behavior, Animal / drug effects ; Cell Count / methods ; Central Nervous System Stimulants / toxicity ; Corpus Striatum / anatomy & histology ; Corpus Striatum / metabolism ; Disease Models, Animal ; Dopamine / metabolism ; Female ; Functional Laterality ; Glial Cell Line-Derived Neurotrophic Factor ; In Situ Hybridization ; In Vitro Techniques ; Medial Forebrain Bundle / injuries ; Nerve Growth Factors / genetics ; RNA, Messenger / biosynthesis ; Rats ; Rats, Wistar ; Rotation ; Up-Regulation / genetics Substance Nomenclature: 0 (Amphetamines) ; 0 (Central Nervous System Stimulants) ; 0 (Gdnf protein, rat) ; 0 (Glial Cell Line-Derived Neurotrophic Factor) ; 0 (Nerve Growth Factors) ; 0 (RNA, Messenger) ; VTD58H1Z2X (Dopamine) Entry Date(s): Date Created: 20030625 Date Completed: 20030929 Latest Revision: 20190718 Update Code: 20240513

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Electro-acupuncture improves behavior and upregulates GDNF mRNA in MFB transected rats.