Alveolar granulocyte colony-stimulating factor and alpha-chemokines in relation to serum levels, pulmonary neutrophilia, and severity of lung injury in ARDS.
In: Chest, Jg. 125 (2004), Heft 1, S. 212-9
Online
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Zugriff:
Objectives: To determine granulocyte colony-stimulating factor (G-CSF), epithelial neutrophil-activating peptide (ENA)-78, and interleukin (IL)-8 in BAL fluid (BALF), epithelial lining fluid (ELF), and serum for establishing the concentration gradient of G-CSF, ENA-78, and IL-8 between the blood and the alveolar space in ARDS and acute lung injury (ALI); and to evaluate the relationship of G-CSF, IL-8, and ENA-78 to pulmonary neutrophilia and severity of lung injury.
Design: Prospective study.
Setting: An adult trauma/surgical ICU.
Patients: Nineteen patients with ARDS and 10 patients with ALI.
Interventions: None.
Measurements and Main Results: BAL and blood sampling simultaneously within 12 h and 24 h after onset of ARDS/ALI; G-CSF was detected in BALF in 18 of 19 patients with ARDS, in 7 of 10 patients with ALI, and in all serum samples. G-CSF in BALF and serum was significantly higher in ARDS than in ALI. ENA-78 was detected in BALF in 14 of 19 patients with ARDS, in 8 of 10 patients with ALI, and in serum of all patients. Levels in BALF and serum were not different between ARDS and ALI. IL-8 was detected in all patients; concentrations in BALF in ARDS were significantly higher than in ALI. Concentrations of G-CSF, ENA-78, and IL-8 in ELF were significantly higher than in serum. G-CSF in BALF and serum and IL-8 in BALF correlated positively with pulmonary neutrophilia. G-CSF in serum and IL-8 in BALF correlated negatively with PaO(2)/fraction of inspired oxygen (FIO(2)) ratio. However, ENA-78 did not show a correlation with neutrophil count or with PaO(2)/FIO(2) ratio.
Conclusions: G-CSF may be pathophysiologically important for accumulation and activation of neutrophils in ARDS. Local G-CSF production is the likely driving force for neutrophils rather than elevation of circulating levels. In comparison to ENA-78, IL-8 seems to be the predominant neutrophil chemoattractant in the early phase of ARDS.
| Titel: |
Alveolar granulocyte colony-stimulating factor and alpha-chemokines in relation to serum levels, pulmonary neutrophilia, and severity of lung injury in ARDS.
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| Autor/in / Beteiligte Person: | Wiedermann, FJ ; Mayr, AJ ; Kaneider, NC ; Fuchs, D ; Mutz, NJ ; Schobersberger, W |
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| Zeitschrift: | Chest, Jg. 125 (2004), Heft 1, S. 212-9 |
| Veröffentlichung: | 2016- : New York : Elsevier ; <i>Original Publication</i>: Chicago : American College of Chest Physicians, 2004 |
| Medientyp: | academicJournal |
| ISSN: | 0012-3692 (print) |
| DOI: | 10.1378/chest.125.1.212 |
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