[Antioxidative activity of oren-gedoku-to (TJ-15) and toki- shakuyaku-san (TJ-23) in the liver microsomes of rats].
In: Ceskoslovenska farmacie, Jg. 41 (1992-10-01), Heft 7-8, S. 250-2
academicJournal
Zugriff:
TJ-15 (Oren-Gedoku-To) inhibited enzymatically (NADPH or CumOOH) and non-enzymatically (Fe-askorbate) induced lipid peroxidation in the rat liver microsomes as assessed by the TBA-reactive product accumulation. TJ-23 (Toki-Shakuyaku-San) had little effect on either system. The protective effect of TJ-15 against lipid peroxidation could not be fully accounted for by its action on microsomal electron transfer, as evaluated by studying the kinetics of reduction of cytochrome C. In a free solution TJ-15 and TJ-23 effectively scavenged OH., radicals, as indicated by the inhibition of ethylene production from KMBA, and O2-. anion radicals, as assessed by the inhibitory effect on the rate of NBT reduction. The present results suggest that TJ-15, yet not TJ-23, is capable to reach hydrophobic intra-membrane sites at concentrations at which it is an effective antioxidant. Thus TJ-15 may be a potentially useful protective agent against free radical-mediated damage.
| Titel: |
[Antioxidative activity of oren-gedoku-to (TJ-15) and toki- shakuyaku-san (TJ-23) in the liver microsomes of rats].
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| Autor/in / Beteiligte Person: | Stefek, M ; Benes, L |
| Zeitschrift: | Ceskoslovenska farmacie, Jg. 41 (1992-10-01), Heft 7-8, S. 250-2 |
| Veröffentlichung: | Praha : Ceskoslovenska Lekarska Spolecnost ; <i>Original Publication</i>: Praha., 1992 |
| Medientyp: | academicJournal |
| ISSN: | 0009-0530 (print) |
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