1800 MHz radiofrequency (mobile phones, different Global System for Mobile communication modulations) does not affect apoptosis and heat shock protein 70 level in peripheral blood mononuclear cells from young and old donors.

Capri, M ; Scarcella, E ; et al.

In: International journal of radiation biology, Jg. 80 (2004-06-01), Heft 6, S. 389-97

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Purpose: To study if prolonged in vitro exposure to 1800MHz radiofrequency (RF) could exert an effect on human peripheral blood mononuclear cells (PBMC) from young and elderly donors by affecting apoptosis, mitochondrial membrane potential and heat shock protein (HSP) 70 levels.

Materials and Methods: Endpoints were analysed in the presence or absence of the apoptosis-inducing agent 2-deoxy-D-ribose. Three different signal modulations typical of the Global System for Mobile communication (GSM) system were applied. The modulations are widely used in mobile telephony (GSM Basic, discontinuous transmission [DTX] and Talk) at specific absorption rates of 1.4 and 2.0 W kg(-1).

Results: In all conditions and for all endpoints tested, there was no significant difference between RF- and sham-exposed cells.

Conclusion: 1800MHz RF could not induce apoptosis by itself or affect the apoptotic phenomenon when induced by an apoptotic agent. Moreover, RF did not modify the mitochondrial functionality and the expression of HSP 70.

Titel:	1800 MHz radiofrequency (mobile phones, different Global System for Mobile communication modulations) does not affect apoptosis and heat shock protein 70 level in peripheral blood mononuclear cells from young and old donors.
Autor/in / Beteiligte Person:	Capri, M ; Scarcella, E ; Bianchi, E ; Fumelli, C ; Mesirca, P ; Agostini, C ; Remondini, D ; Schuderer, J ; Kuster, N ; Franceschi, C ; Bersani, F
Link:	Volltext (PDF)
Zeitschrift:	International journal of radiation biology, Jg. 80 (2004-06-01), Heft 6, S. 389-97
Veröffentlichung:	London ; New York : Taylor & Francis, [c1988-, 2004
Medientyp:	academicJournal
ISSN:	0955-3002 (print)
DOI:	10.1080/09553000410001702346
Schlagwort:	Adult Aged Aged, 80 and over Apoptosis drug effects Deoxyribose pharmacology Humans In Vitro Techniques Leukocytes, Mononuclear cytology Leukocytes, Mononuclear drug effects Leukocytes, Mononuclear metabolism Apoptosis radiation effects Cell Phone HSP70 Heat-Shock Proteins metabolism Leukocytes, Mononuclear radiation effects Radio Waves adverse effects
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, Non-U.S. Gov't Language: English [Int J Radiat Biol] 2004 Jun; Vol. 80 (6), pp. 389-97. MeSH Terms: Cell Phone* ; Apoptosis / radiation effects ; HSP70 Heat-Shock Proteins / metabolism ; Leukocytes, Mononuclear / radiation effects ; Radio Waves / adverse effects ; Adult ; Aged ; Aged, 80 and over ; Apoptosis / drug effects ; Deoxyribose / pharmacology ; Humans ; In Vitro Techniques ; Leukocytes, Mononuclear / cytology ; Leukocytes, Mononuclear / drug effects ; Leukocytes, Mononuclear / metabolism Substance Nomenclature: 0 (HSP70 Heat-Shock Proteins) ; 533-67-5 (Deoxyribose) Entry Date(s): Date Created: 20040915 Date Completed: 20040928 Latest Revision: 20171116 Update Code: 20231215

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