Antenatal risk factors associated with the development of lenticulostriate vasculopathy (LSV) in neonates.

Mittendorf, R ; Kuban, K ; et al.

In: Journal of perinatology : official journal of the California Perinatal Association, Jg. 25 (2005-02-01), Heft 2, S. 101-7

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Objective: To determine the antenatal risk factors associated with neonatal lenticulostriate vasculopathy (LSV).

Study Design: Women in preterm labor were randomized to magnesium sulfate (MgSO4), other tocolytic, or saline control. The surviving babies underwent head ultrasounds (HUS) (weeks of life 1, 2, and 4) and periodic developmental examinations (months 4, 8, 12, and 18).

Results: Of 140 infants, 17.1% (24) had neonatal intraventricular hemorrhage (IVH), and 10.0% (14) had LSV (half of the latter (7 of 14) had both IVH and LSV). In a regression model in which other risk factors were controlled for, the association between antenatal exposures to tocolytic MgSO4 >or=50 g and LSV were significant (adjusted odds ratio (OR), 8.3; 95% confidence interval (CI), 1.5 to 45.0; p=0.01).

Conclusion: Based on our data and their analyses, we infer that antenatal exposure to high-dosage, tocolytic MgSO4 may be associated with LSV.

Titel:	Antenatal risk factors associated with the development of lenticulostriate vasculopathy (LSV) in neonates.
Autor/in / Beteiligte Person:	Mittendorf, R ; Kuban, K ; Pryde, PG ; Gianopoulos, JG ; Yousefzadeh, D
Link:	Volltext (PDF)
Zeitschrift:	Journal of perinatology : official journal of the California Perinatal Association, Jg. 25 (2005-02-01), Heft 2, S. 101-7
Veröffentlichung:	2001- : New York, NY : Nature Publishing Group ; <i>Original Publication</i>: [Philadelphia, Pa. : W.B. Saunders, c1984-, 2005
Medientyp:	academicJournal
ISSN:	0743-8346 (print)
DOI:	10.1038/sj.jp.7211212
Schlagwort:	Adult Dose-Response Relationship, Drug Female Follow-Up Studies Humans Infant, Newborn Magnesium Sulfate administration & dosage Obstetric Labor, Premature drug therapy Pregnancy Prospective Studies Risk Factors Tocolytic Agents administration & dosage Basal Ganglia Cerebrovascular Disease chemically induced Cerebral Hemorrhage chemically induced Magnesium Sulfate adverse effects Tocolytic Agents adverse effects
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Language: English [J Perinatol] 2005 Feb; Vol. 25 (2), pp. 101-7. MeSH Terms: Basal Ganglia Cerebrovascular Disease / chemically induced ; Cerebral Hemorrhage / chemically induced ; Magnesium Sulfate / adverse effects ; Tocolytic Agents / adverse effects ; Adult ; Dose-Response Relationship, Drug ; Female ; Follow-Up Studies ; Humans ; Infant, Newborn ; Magnesium Sulfate / administration & dosage ; Obstetric Labor, Premature / drug therapy ; Pregnancy ; Prospective Studies ; Risk Factors ; Tocolytic Agents / administration & dosage Substance Nomenclature: 0 (Tocolytic Agents) ; 7487-88-9 (Magnesium Sulfate) Entry Date(s): Date Created: 20041022 Date Completed: 20050607 Latest Revision: 20061115 Update Code: 20231215

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