The class A macrophage scavenger receptor attenuates CXC chemokine production and the early infiltration of neutrophils in sterile peritonitis.
In: Journal of immunology (Baltimore, Md. : 1950), Jg. 173 (2004-11-15), Heft 10, S. 6427-32
academicJournal
Zugriff:
The macrophage scavenger receptor (SR-A) is a multifunctional receptor that is associated with several important pathological conditions, including atherosclerosis. In this study, we show, using a sterile peritonitis model, that it can regulate the inflammatory response. SR-A null mice display an increased initial granulocytic infiltration because of overproduction of the CXC chemokines, MIP-2 and keratinocyte-derived cytokine. This differential response is dependent upon particle internalization and can be mimicked by advanced glycation end product-BSA-conjugated latex beads. Thus SR-A is a nonactivating receptor, which is the first example of a pattern recognition receptor that serves to counter the activities of proinflammatory receptors and attenuates the production of specific chemokines to ensure an inflammatory response of the appropriate magnitude.
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The class A macrophage scavenger receptor attenuates CXC chemokine production and the early infiltration of neutrophils in sterile peritonitis.
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Autor/in / Beteiligte Person: | Cotena, A ; Gordon, S ; Platt, N |
Zeitschrift: | Journal of immunology (Baltimore, Md. : 1950), Jg. 173 (2004-11-15), Heft 10, S. 6427-32 |
Veröffentlichung: | Bethesda, MD : American Association of Immunologists ; <i>Original Publication</i>: Baltimore : Williams & Wilkins, c1950-, 2004 |
Medientyp: | academicJournal |
ISSN: | 0022-1767 (print) |
DOI: | 10.4049/jimmunol.173.10.6427 |
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