Larger than Dbl: new structural insights into RhoA activation.
In: Trends in biochemical sciences, Jg. 30 (2005-04-01), Heft 4, S. 163-5
academicJournal
Zugriff:
Dbl homology (DH) domains are almost always followed immediately by pleckstrin homology (PH) domains in Dbl family proteins, and these DH-PH fragments directly activate GDP-bound Rho GTPases by catalyzing the exchange of GDP for GTP. New crystal structures of the DH-PH domains from leukemia-associated Rho guanine nucleotide exchange factor (RhoGEF) and PDZ-RhoGEF bound to RhoA reveal how DH-PH domains cooperate to specifically activate Rho GTPases.
Titel: |
Larger than Dbl: new structural insights into RhoA activation.
|
---|---|
Autor/in / Beteiligte Person: | Rossman, KL ; Sondek, J |
Link: | |
Zeitschrift: | Trends in biochemical sciences, Jg. 30 (2005-04-01), Heft 4, S. 163-5 |
Veröffentlichung: | Cambridge (Eng) : Elsevier Trends Journals ; <i>Original Publication</i>: Amsterdam, Published for the International Union of Biochemistry by Elsevier Scientific Pub. Co., 2005 |
Medientyp: | academicJournal |
ISSN: | 0968-0004 (print) |
DOI: | 10.1016/j.tibs.2005.02.002 |
Schlagwort: |
|
Sonstiges: |
|