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Growth-related oncogene protein-alpha (GRO-alpha)/CXCLl is a chemokine that activates neutrophils and plays an important role in inflammatory reactions. Polyinosinic-polycytidylic acid (poly IC) is a synthetic double-stranded RNA (dsRNA), which is a ligand for Toll-like receptor-3. Poly IC mimics viral infection when applied to cells and induces inflammatory and immune responses. In the present study, we found the induction of GRO-alpha in BEAS-2B bronchial epithelial cells treated with poly IC. Pretreatment of cells with 2-aminopurine, an inhibitor for dsRNA-dependent protein kinase (PKR), inhibited the expression of GRO-alpha-induced by poly IC. Overexpression of interferon-regulatory factor-3 (IRF-3) or retinoic-acid inducible gene-I (RIG-I) enhanced the induction of GRO-alpha by poly IC. PKR, IRF-3, and RIG-I may be involved in the poly IC-induced expression of GRO-alpha in BEAS-2B cells. Airway viral infection may elicit GRO-alpha expression in the bronchial epithelium, which may be implicated in inflammatory and immune reactions.

Titel:	Polyinosinic-polycytidylic acid induces the expression of GRO-alpha in BEAS-2B cells.
Autor/in / Beteiligte Person:	Yamashita, K ; Imaizumi, T ; Taima, K ; Fujita, T ; Ishikawa, A ; Yoshida, H ; Oyama, C ; Satoh, K
Link:	View record at Springer (Volltext) E-Journal im Bestand der UB Hagen?
Zeitschrift:	Inflammation, Jg. 29 (2005-02-01), Heft 1, S. 17-21
Veröffentlichung:	1999- : New York, NY : Kluwer Academic/Plenum Publishers ; <i>Original Publication</i>: New York, Plenum Press., 2005
Medientyp:	academicJournal
ISSN:	0360-3997 (print)
DOI:	10.1007/s10753-006-8964-4
Schlagwort:	Cell Line Chemokine CXCL1 Chemokines, CXC analysis Culture Media, Conditioned analysis Dose-Response Relationship, Drug Enzyme-Linked Immunosorbent Assay Humans Intercellular Signaling Peptides and Proteins analysis RNA, Messenger metabolism Reverse Transcriptase Polymerase Chain Reaction Bronchi cytology Chemokines, CXC metabolism Epithelial Cells metabolism Intercellular Signaling Peptides and Proteins metabolism Interferon Inducers pharmacology Poly I-C pharmacology
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Inflammation] 2005 Feb; Vol. 29 (1), pp. 17-21. MeSH Terms: Bronchi / cytology ; Chemokines, CXC / metabolism ; Epithelial Cells / metabolism ; Intercellular Signaling Peptides and Proteins / metabolism ; Interferon Inducers / pharmacology ; Poly I-C / pharmacology ; Cell Line ; Chemokine CXCL1 ; Chemokines, CXC / analysis ; Culture Media, Conditioned / analysis ; Dose-Response Relationship, Drug ; Enzyme-Linked Immunosorbent Assay ; Humans ; Intercellular Signaling Peptides and Proteins / analysis ; RNA, Messenger / metabolism ; Reverse Transcriptase Polymerase Chain Reaction References: J Biol Chem. 2005 Feb 18;280(7):5571-80. (PMID: 15579900) ; J Interferon Cytokine Res. 2002 Jan;22(1):73-6. (PMID: 11846977) ; Biochem Biophys Res Commun. 2002 Mar 22;292(1):274-9. (PMID: 11890704) ; Life Sci. 2004 Jul 23;75(10 ):1171-80. (PMID: 15219805) ; Cytokine. 2003 Nov 7;24(3):67-73. (PMID: 14581000) ; J Exp Med. 1990 Apr 1;171(4):1091-100. (PMID: 2182761) ; Eur Respir J. 2002 Aug;20(2):369-75. (PMID: 12212969) ; Mol Carcinog. 1988;1(3):151-60. (PMID: 2855021) ; Life Sci. 2002 May 17;70(26):3179-90. (PMID: 12008100) ; Endothelium. 2004 May-Aug;11(3-4):169-73. (PMID: 15370293) ; Nat Immunol. 2004 Jul;5(7):730-7. (PMID: 15208624) ; Am J Physiol. 1994 Mar;266(3 Pt 1):L278-86. (PMID: 8166297) ; Tohoku J Exp Med. 2004 Feb;202(2):69-76. (PMID: 14998300) ; Am J Respir Cell Mol Biol. 2003 Jun;28(6):731-7. (PMID: 12600836) ; Am J Respir Cell Mol Biol. 2004 Sep;31(3):358-64. (PMID: 15191912) ; Oncogene. 1999 Nov 1;18(45):6112-20. (PMID: 10557102) ; Exp Lung Res. 2005 Apr;31(3):361-75. (PMID: 15962714) ; J Exp Med. 1990 May 1;171(5):1797-802. (PMID: 2185333) ; Pharmacol Ther. 1998 Apr;78(1):29-46. (PMID: 9593328) ; Clin Exp Allergy. 2004 May;34(5):745-52. (PMID: 15144466) ; J Inflamm. 1995;45(3):143-51. (PMID: 8597869) ; J Cell Physiol. 1986 Dec;129(3):375-84. (PMID: 3465735) ; Am J Physiol. 1998 Jul;275(1 Pt 1):L87-95. (PMID: 9688939) Substance Nomenclature: 0 (CXCL1 protein, human) ; 0 (Chemokine CXCL1) ; 0 (Chemokines, CXC) ; 0 (Culture Media, Conditioned) ; 0 (Intercellular Signaling Peptides and Proteins) ; 0 (Interferon Inducers) ; 0 (RNA, Messenger) ; O84C90HH2L (Poly I-C) Entry Date(s): Date Created: 20060228 Date Completed: 20060511 Latest Revision: 20181113 Update Code: 20240513

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Polyinosinic-polycytidylic acid induces the expression of GRO-alpha in BEAS-2B cells.